1377585-41-5

Upstream product

• 100-68-5 methyl-phenyl-thioether 
• 1193-82-4 racemic methyl phenyl sulfoxide 
• 4381-25-3 S-methyl-S-phenylsulfoximine 
• 1711-06-4 3-Methylbenzoyl chloride 
• 67087-35-8 N-chloro-S-methyl-S-phenyl sulfoximine 
• 108-38-3 m-xylene 
• 99-04-7 m-Toluic acid 
• 201230-82-2 carbon monoxide 
• 625-95-6 3-Iodotoluene 
• 67-66-3 chloroform 
• 57494-03-8 2-methyl-1-(3-methylphenyl)propan-1-one 
• 10335-81-6 3-methylphenylhydroxamic acid 
• 620-23-5 m-tolyl aldehyde 

Downstream Products

• 1377585-09-5 N-[2-acetoxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1377585-37-9 N-[2-hydroxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1377585-31-3 N-[2,6-diacetoxy-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1426922-36-2 N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-00-6 N-[(E)-2-(3-ethoxy-3-oxoprop-1-en-1-yl)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-12-0 N-[2-(3-ethoxy-3-oxopropyl)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-05-1 N-[(E)-2-(3-methoxy-3-oxoprop-1-en-1-yl)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-06-2 N-[(E)-2-(3-n-butoxy-3-oxoprop-1-en-1-yl)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-07-3 N-[(E)-2-(2-(phenylsulfonyl)vinyl)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 1616088-08-4 N-[(E)-2-(3-oxopent-1-enyl)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 

Relevant academic research and scientific papers

Visible light-induced C-C bond cleavage in a multicomponent reaction cascade allowing acylations of sulfoximines with ketones

Visible light induces C-C-bond cleavage reactions of ketones, which can be utilized forN-acylations of sulfoximines. No (photo)catalyst is required, and the reactions occur at ambient temperature in air. The substrate scope is broad for both ketones and sulfoximines. For convertingNH-sulfoximines, the presence of NBS is essential.

Interweaving Visible-Light and Iron Catalysis for Nitrene Formation and Transformation with Dioxazolones

Herein, visible-light-driven iron-catalyzed nitrene transfer reactions with dioxazolones for intermolecular C(sp3)-N, N=S, and N=P bond formation are described. These reactions occur with exogenous-ligand-free process and feature satisfactory to excellent yields (up to 99 %), an ample substrate scope (109 examples) under mild reaction conditions. In contrast to intramolecular C?H amidations strategies, an intermolecular regioselective C?H amidation via visible-light-induced nitrene transfer reactions is devised. Mechanistic studies indicate that the reaction proceeds via a radical pathway. Computational studies show that the decarboxylation of dioxazolone depends on the conversion of ground sextet state dioxazolone-bounding iron species to quartet spin state via visible-light irradiation.

Method for synthesizing sulfoxide imide acylate

The invention discloses a method for synthesizing sulfoxide imide acylate by visible light induction under the condition that no metal catalysts are provided, namely sulfoxide imide acylate is prepared under a mild reaction condition and the combined acti

Visible light promoted synthesis of N-aroylsulfoximines by oxidative C-H acylation of NH-sulfoximines

The visible light-promoted synthesis of N-aroylsulfoximines has been accomplished via an oxidative dehydrogenative coupling at room temperature under air without the addition of a photosensitizer, metal catalyst, or base. This process exhibits good functional group tolerance, allows facile isolation and purification, and affords N-aroylsulfoximines with high efficiency. The efficiency of the newly developed protocol is described in detail with 27 examples with yields ranging from 80% to 96%. Furthermore, the chirality of the NH-sulfoximine is completely maintained in the desired N-aroylsulfoximine product (99% ee).

One-Pot Unsymmetrical {[4 + 2] and [4 + 2]} Double Annulations of o/ o′-C-H Bonds of Arenes: Access to Unusual Pyranoisoquinolines

With the aid of a transformable sulfoximine directing group, unprecedented one-pot unsymmetrical double annulations {[4 + 2] and [4 + 2]} of hetero(arenes) with alkynes are revealed under Ru(II) catalysis. Functionalization of both ortho-C-H bonds of (hetero)arene is reflected in the building of unusual 6,6-fused pyranoisoquinoline skeletons. Construction of four [(C-C)-(C-N) and (C-C)-(C-O)] bonds occurs in one step under single catalytic conditions. The challenging unsymmetrical double annulations of both o-C-H bonds of arenes with two distinct alkynes is effectively demonstrated. Control experiments and deuterium scrambling findings are shown.

Palladium catalyzed aroylation of NH-sulfoximines with aryl halides using chloroform as the CO precursor

A palladium-catalyzed aroylation of NH-sulfoximines for the efficient synthesis of N-aroyl sulfoximines from aryl halides and chloroform has been developed. The mild reaction conditions (temperature, catalyst loading) and the use of a CO surrogate render this transformation a useful method for the synthesis of N-aroyl sulfoximines from available feedstock.

Iron-Catalyzed One-Pot N-Aroylation of NH-Sulfoximines with Methylarenes through Benzylic C-H Bond Oxidation

An efficient catalytic method has been developed for the synthesis of N-aroylated sulfoximines from readily available toluenes (methylarenes) as source of the aroyl coupling partner and NH-sulfoximines, employing an environmentally benign iron catalyst. T

Palladium nanoparticles catalyzed aroylation of: NH -sulfoximines with aryl iodides

A novel approach towards aroylation of NH-sulfoximines using Pd nanoparticles stabilized by a binaphthyl backbone (Pd-BNP) has been developed. This synthetic protocol involves the Pd-BNP promoted carbon monoxide insertion of aryl iodides to form an aroyl intermediate which further reacts with NH-sulfoximines to form N-aroyl sulfoximine derivatives in good to excellent yields. The Pd-BNP catalyst was recovered and reused up to six times.

Sulfoximinocarbonylation of aryl halides using heterogeneous Pd/C catalyst

A three component protocol has been developed for the synthesis of N-aroyl sulfoximines by the carbonylation of aryl halides followed by nucleophilic attack of NH-sulfoximines. This reaction tolerates a range of aryl iodides and sulfoximines to provide th

Transition metal-free aroylation of NH-sulfoximines with methyl arenes

A novel protocol towards N-aroylated sulfoximines from NH-sulfoximines and methyl arenes was herein demonstrated. The reaction took place in the presence of elemental iodine, requiring no external organic solvents, transition metal-catalysts or ligands. The aroylated products were obtained from the oxidative transformation in moderate to excellent yields (up to 94% yield) with a broad substrate scope (35 examples) through a radical pathway.