methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)

Base Information

Chemical Name:methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)
CAS No.:1407977-98-3
Molecular Formula:C₂₁H₁₈F₄N₈O₂
Molecular Weight:490.42
Hs Code.:

Synonyms:methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)

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Chemical Property of methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)

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Technology Process of methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)

There total 3 articles about methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 6.0%

: 23199-56-6
2,2,2-trifluoroethyltrichloromethanesulfonate

: methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}carbamate formate

: 1407977-98-3
methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)

Guidance literature:: With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 104h;

Reference yield:

: 2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidine-4,5,6-triamine trihydrochloride

: 1407977-98-3
methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)

Guidance literature:: Multi-step reaction with 2 steps

1: pyridine / 16 h / 0 - 20 °C

2: sodium hydride / tetrahydrofuran; mineral oil / 104 h / 0 - 20 °C

With pyridine; sodium hydride; In tetrahydrofuran; mineral oil;

Reference yield:

: 1407978-23-7
2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]-5-[(E)-phenyldiazenyl]pyrimidine-4,6-diamine

: 1407977-98-3
methyl {4,6-diamino-2-[7-(2-fluorobenzyl)imidazo[1,5-b]pyridazin-5-yl]pyrimidin-5-yl}(2,2,2-trifluoroethyl)

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen; palladium 10% on activated carbon / methanol; N,N-dimethyl-formamide / 18 h

2: pyridine / 16 h / 0 - 20 °C

3: sodium hydride / tetrahydrofuran; mineral oil / 104 h / 0 - 20 °C

With pyridine; palladium 10% on activated carbon; hydrogen; sodium hydride; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; mineral oil;