4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine

Base Information

• Chemical Name: 4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine
• CAS No.: 1403669-20-4
• Molecular Formula: C₁₆H₁₈ClN₃O₃
• Molecular Weight: 335.79
• Mol file: 1403669-20-4.mol

Synonyms:4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine

Chemical Property of 4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine

There total 1 articles about 4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 40.0%

morpholine (110-91-8,99108-56-2) + 2,4,6-trichloropyrimidine (3764-01-0) + 4-Methoxybenzyl alcohol (105-13-5) → 4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine (1403669-20-4) + 4-(6-chloro-2-((4-methoxybenzyl)oxy)pyrimidin-4-yl)morpholine (1403669-21-5) + 4-(2-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-4-yl)morpholine (1403669-22-6)

Guidance literature:

2,4,6-trichloropyrimidine; 4-Methoxybenzyl alcohol; With caesium carbonate; In acetonitrile; at 20 ℃; for 72h;

morpholine; In acetonitrile; at 20 ℃; for 16h;

DOI:10.1021/acs.jmedchem.9b01561

Reference yield: 69.0%

2-benzylpyrrolidine (35840-91-6) + 4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine (1403669-20-4) → 4-(4-(2-benzylpyrrolidin-1-yl)-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 90 ℃; for 21h;

DOI:10.1021/acs.jmedchem.1c00114

Reference yield:

4-(4-chloro-6-((4-methoxybenzyl)oxy)pyrimidin-2-yl)morpholine (1403669-20-4) → C15H18N4O2 (1403669-00-0)

Guidance literature:

Multi-step reaction with 2 steps

1: caesium carbonate; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl / 1,4-dioxane / 0.5 h / 130 °C / Microwave irradiation; Inert atmosphere

2: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

With palladium diacetate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; trifluoroacetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2012.08.101

upstream raw materials:

morpholine

2,4,6-trichloropyrimidine

4-Methoxybenzyl alcohol

Downstream raw materials:

C₁₅H₁₈N₄O₂