N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester

Base Information

• Chemical Name: N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester
• CAS No.: 620960-59-0
• Molecular Formula: C₁₉H₂₆Br₂N₂O₇
• Molecular Weight: 554.233
• Mol file: 620960-59-0.mol

Synonyms:N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester

Chemical Property of N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester

There total 1 articles about N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

Boc-Thr-OH (2592-18-9) + 3,5-dibromotyrosine methyl ester hydrochloride (61039-29-0) → N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester (620960-59-0)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2003.08.105 DOI:10.1016/j.tet.2004.04.062

Reference yield:

N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester (620960-59-0) → (S)-2-((2S,3R)-2-Amino-3-hydroxy-butyrylamino)-3-(3,5-dibromo-4-hydroxy-phenyl)-propionic acid methyl ester

Guidance literature:

With trifluoroacetic acid; In dichloromethane;

DOI:10.1016/j.tetlet.2003.08.105

Reference yield:

N-tert-butoxycarbonyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester (620960-59-0) → N-tert-butoxycarbonyl-o,o'-diiodo-L-tyrosyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester (620960-60-3)

Guidance literature:

Multi-step reaction with 2 steps

1: TFA / CH₂Cl₂

2: BOP; Et₃N / dimethylformamide

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.tetlet.2003.08.105

upstream raw materials:

Boc-Thr-OH

3,5-dibromotyrosine methyl ester hydrochloride

Downstream raw materials:

N-tert-butoxycarbonyl-o,o'-diiodo-L-tyrosyl-L-threonyl-o,o'-dibromo-L-tyrosine methyl ester