2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester

Base Information

• Chemical Name: 2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester
• CAS No.: 340291-80-7
• Molecular Formula: C₁₉H₂₀N₂O₅
• Molecular Weight: 356.378
• Mol file: 340291-80-7.mol

Synonyms:2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester

Chemical Property of 2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester

There total 1 articles about 2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

N-Cbz-Ala (1142-20-7) + 2-carbomethoxyaniline (134-20-3) → 2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester (340291-80-7)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 36h;

DOI:10.1021/jo001696h

Reference yield: 82.0%

2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester (340291-80-7) → 2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid (229160-73-0)

Guidance literature:

With lithium hydroxide; water; In tetrahydrofuran; methanol; at 20 - 50 ℃; for 4h;

DOI:10.1021/jo001696h

Reference yield:

2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid methyl ester (340291-80-7) → [1-(4-oxo-4H-3,1-benzoxazin-2-yl)-ethyl]-carbamic acid benzyl ester

Guidance literature:

Multi-step reaction with 2 steps

1: 82 percent / LiOH; H₂O / methanol; tetrahydrofuran / 4 h / 20 - 50 °C

2: 68 percent / DCC; 1-hydroxybenzotriazole / dimethylformamide / 20 °C

With lithium hydroxide; water; benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;

DOI:10.1021/jo001696h

upstream raw materials:

N-Cbz-Ala

2-carbomethoxyaniline

Downstream raw materials:

2-(2-benzyloxycarbonylamino-propanoylamino)-benzoic acid