3-(4-methylbenzyl)-2-phenylquinoline

Base Information

• Chemical Name: 3-(4-methylbenzyl)-2-phenylquinoline
• CAS No.: 1436413-27-2
• Molecular Formula: C₂₃H₁₉N
• Molecular Weight: 309.411
• Mol file: 1436413-27-2.mol

Synonyms:3-(4-methylbenzyl)-2-phenylquinoline

Chemical Property of 3-(4-methylbenzyl)-2-phenylquinoline

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 3-(4-methylbenzyl)-2-phenylquinoline

There total 5 articles about 3-(4-methylbenzyl)-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-Aminobenzyl alcohol (5344-90-1) + 4-methyl-chalcone (4224-87-7) → 3-(4-methylbenzyl)-2-phenylquinoline (1436413-27-2) + C23H23N

Guidance literature:

With C₁₉H₂₇ClIrN₃O⁽¹⁺⁾*Cl^(1-); potassium hydroxide; In water; at 100 ℃; for 14h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1055/a-1545-7563

Reference yield: 89.0%

2-Aminobenzyl alcohol (5344-90-1) + 4-methyl-chalcone (4224-87-7) → 3-(4-methylbenzyl)-2-phenylquinoline (1436413-27-2)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; potassium tert-butylate; In tert-Amyl alcohol; at 20 ℃; for 12h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c8ob01321g

Reference yield:

2-Aminobenzyl alcohol (5344-90-1) + 1-phenyl-3-(4-tolyl)propan-1-one (1669-50-7) → 3-(4-methylbenzyl)-2-phenylquinoline (1436413-27-2)

Guidance literature:

With oxygen; potassium hydroxide; In toluene; at 125 ℃; for 21h; Sonication; Inert atmosphere;

DOI:10.1002/cctc.201200496

upstream raw materials:

4-Methylbenzyl alcohol

acetophenone

2-Aminobenzyl alcohol

1-phenyl-3-(4-tolyl)propan-1-one

Refernces

• 1、 Xiong, Biao,Wang, Yingying,Liu, Yuan,Bao, Yandan,Liu, Zhaoguo,Zhang, Yanan,Ling, Yong. "Straightforward synthesis of quinolines from enones and 2-aminobenzyl alcohols using an iridium-catalyzed transfer hydrogenative strategy". supporting information. p. 5707 - 5711. Retrieved 2018/08/17.