1669-50-7

Basic information

• Product Name: 3-(4-METHYLPHENYL)PROPIOPHENONE
• Synonyms: 3-(4-METHYLPHENYL)PROPIOPHENONE
• CAS NO: 1669-50-7
• Molecular Formula: C₁₆H₁₆O
• Molecular Weight: 224.3
• Mol File: 1669-50-7.mol
• Article Data: 121

Chemical Properties

• Melting Point: 33-34 °C
• Boiling Point: 368.772°C at 760 mmHg
• Flash Point: 160.088°C
• Appearance: /
• Density: 1.046g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.569
• CAS DataBase Reference: 3-(4-METHYLPHENYL)PROPIOPHENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-METHYLPHENYL)PROPIOPHENONE(1669-50-7)
• EPA Substance Registry System: 3-(4-METHYLPHENYL)PROPIOPHENONE(1669-50-7)

Safety Data

• Hazardous Substances Data: 1669-50-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C16H16O/c1-13-7-9-14(10-8-13)11-12-16(17)15-5-3-2-4-6-15/h2-10H,11-12H2,1H3

Upstream product

• 1669-54-1 1-(4-methylphenyl)-3-phenylprop-2-en-1-ol 
• 22252-14-8 (E)-3-(4-methylphenyl)-1-phenyl-2-propen-1-one 
• 589-18-4 4-Methylbenzyl alcohol 
• 98-85-1 1-Phenylethanol 
• 104-87-0 4-methyl-benzaldehyde 
• 936-59-4 3-chloropropiophenone 
• 5720-05-8 4-methylphenylboronic acid 
• 624-31-7 4-tolyl iodide 
• 37442-45-8 ethyl 2-(hydroxy(phenyl)methyl)propenoate 
• 100-52-7 benzaldehyde 
• 98-86-2 acetophenone 
• 122-00-9 para-methylacetophenone 
• 166824-01-7 α-phenyl p-methylcinnamyl alcohol 
• 14802-30-3 (E)-1-(4-methylphenyl)-3-phenyl-2-propen-1-one 

Downstream Products

• 1436413-27-2 3-(4-methylbenzyl)-2-phenylquinoline 
• 93-89-0 benzoic acid ethyl ester 
• 288310-94-1 1,1,1-trifluoro-4-(4-methylphenyl)butan-2-one 

Relevant articles and documents

Visible Light-Promoted Friedel-Crafts-Type Chloroacylation of Alkenes to β-Chloroketones

The photoredox chloroacylation of alkenes has been developed as a substitute for the Friedel-Crafts acylation of alkenes to β-chloroketones. The direct generation of acyl radical species from acid chlorides under the photoredox conditions allows the formation of β-chloroketones without dehydrochlorination with the help of KHCO3. The synthetic utility of the current method is demonstrated in the one-pot synthesis of dihydroisoxazole, dihydropyrazole, and dihydropyrimidine-2-thione in 1 mmol scale.

Arylboronic Acid Catalyzed Dehydrative Mono-/Dialkylation Reactions of β-Ketoacids and Alcohols

The dehydrative mono-/dialkylation reactions of alcohols and β-ketoacids were realized under arylboronic acid catalysis, furnishing a series of β-aryl ketones and β-ketoesters in yields of 15–99%, with CO2 and H2O being the byproduct

Nickel-Catalyzed Selective Synthesis of α-Alkylated Ketones via Dehydrogenative Cross-Coupling of Primary and Secondary Alcohols

Herein, we describe an isolable, air-stable, homogeneous, nickel catalyst that performs dehydrogenative cross-coupling reaction between secondary and primary alcohols to result α-alkylated ketone products selectively. The sequence of steps involve in this one-pot reaction is dehydrogenation of both alcohols, condensation between the ketone and the aldehyde, and hydrogenation of the in situ-generated α,β-unsaturated ketone. Preliminary mechanistic investigation hints a radical mechanism following borrowing hydrogen reaction. (Figure presented.).

BTP-Rh@g-C3N4 as an efficient recyclable catalyst for dehydrogenation and borrowing hydrogen reactions

Highly active catalysts play an important role in modern catalysis. A novel and efficient ligand benzotriazole-pyrimidine (BTP) and the corresponding rhodium composite on C3N4 were successfully synthesized. The resulting rhodium composite was fully characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), x-ray diffraction (XRD), thermogravimetric analysis (TGA), and x-ray photoelectron spectroscopy (XPS). The obtained composite exhibited good catalytic activity and good recovery performance in the synthesis of quinoxaline from 2-aminobenzyl alcohol and benzonitrile, and more than 20 quinoxalines were obtained in good yields. Additionally, it also showed that rhodium composite could achieved good catalytic performance in the synthesis of functionalized ketone through borrowing hydrogen strategy.