7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Base Information

Chemical Name:7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine
CAS No.:635698-41-8
Molecular Formula:C₂₈H₂₆Cl₂N₄O₃S
Molecular Weight:569.511
Hs Code.:

Synonyms:7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

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Chemical Property of 7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

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Technology Process of 7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

There total 2 articles about 7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: 62459-02-3
7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione

: 98-59-9
p-toluenesulfonyl chloride

: 95-00-1
2,4-dichloro-benzenemethanamine

: 635698-41-8
7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Guidance literature:: 7-benzyl-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine-2,4(1H,3H)-dione; With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 1.5h;

p-toluenesulfonyl chloride; In N,N-dimethyl-formamide; for 1.25h;

2,4-dichloro-benzenemethanamine; With triethylamine; In tetrahydrofuran; at 20 ℃; for 24h;

Reference yield:

: 52763-21-0
ethyl 1-benzyl-3-oxopiperidine-4-carboxylate hydrochloride

: 635698-41-8
7-benzyl-4-(2,4-dichlorobenzylamino)-2-(4-toluenesulfonyloxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium methylate / ethanol / 17 h / Heating / reflux

2.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C

2.2: 1.25 h

2.3: 24 h / 20 °C

With sodium methylate; sodium hydride; In ethanol; N,N-dimethyl-formamide;