3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

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Chemical Name:3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine
CAS No.:1188523-11-6
Molecular Formula:C₄₀H₃₆F₄N₄O₉
Molecular Weight:792.741
Hs Code.:

Synonyms:3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

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Chemical Property of 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

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Technology Process of 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

There total 11 articles about 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1188523-08-1
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine

: 407-25-0
trifluoroacetic anhydride

: 1188523-11-6
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

Guidance literature:: 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-2-oxophenoxazine; With hydrogen; triethylamine; palladium 10% on activated carbon; In methanol; for 4h;

trifluoroacetic anhydride; With pyridine; at 0 ℃; for 3h;

Reference yield:

: 1188522-91-9
5-bromo-3',5'-diacetyl-2'-fluoro-2'-deoxyuridine

: 1188523-11-6
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: 1,2,3-triazole; triethylamine; trichlorophosphate / acetonitrile / 3.33 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 18 h / 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice

4.1: triethylamine / ethanol / 8 h / 90 °C

4.2: 3 h / 20 °C

5.1: pyridine / 4 h / 20 °C

6.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 4 h

7.1: trifluoroacetic anhydride / pyridine

With 1,2,3-triazole; di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic anhydride; trichlorophosphate; palladium 10% on activated carbon; In pyridine; methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1188522-93-1
C₁₅H₁₅BrFN₅O₆

: 1188523-11-6
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine / dichloromethane / 18 h / 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice

3.1: triethylamine / ethanol / 8 h / 90 °C

3.2: 3 h / 20 °C

4.1: pyridine / 4 h / 20 °C

5.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 4 h

6.1: trifluoroacetic anhydride / pyridine

With di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic anhydride; palladium 10% on activated carbon; In pyridine; methanol; ethanol; dichloromethane;