3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

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Chemical Name:3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite
CAS No.:1188523-13-8
Molecular Formula:C₄₉H₅₃F₄N₆O₁₀P
Molecular Weight:992.961
Hs Code.:

3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Synonyms:3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

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Chemical Property of 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

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Technology Process of 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

There total 10 articles about 3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1188523-11-6
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine

: 102691-36-1
N,N,N',N'-tetraisopropyl 2-cyanoethylphosphorodiamidite

: 1188523-13-8
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Guidance literature:: With 4,5-dicyano-1H-imidazole; In dichloromethane;

Reference yield:

: 1188522-91-9
5-bromo-3',5'-diacetyl-2'-fluoro-2'-deoxyuridine

: 1188523-13-8
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 8 steps

1.1: 1,2,3-triazole; triethylamine; trichlorophosphate / acetonitrile / 3.33 h / 0 - 20 °C

2.1: triethylamine / dichloromethane / 18 h / 20 °C

3.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice

4.1: triethylamine / ethanol / 8 h / 90 °C

4.2: 3 h / 20 °C

5.1: pyridine / 4 h / 20 °C

6.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 4 h

7.1: trifluoroacetic anhydride / pyridine

8.1: 4,5-dicyano-1H-imidazole / dichloromethane

With 1,2,3-triazole; 4,5-dicyano-1H-imidazole; di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic anhydride; trichlorophosphate; palladium 10% on activated carbon; In pyridine; methanol; ethanol; dichloromethane; acetonitrile;

Reference yield:

: 1188522-93-1
C₁₅H₁₅BrFN₅O₆

: 1188523-13-8
3-(5'-O-dimethoxytrityl-2'-fluoro-2'-deoxy-β-D-ribofuranosyl)-9-(2-N-trifluoroacetamido-ethoxy)-1,3-diaza-2-oxophenoxazine 3'-O-(2-cyanoethyl)-N,N-diisopropylphosphoramidite

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine / dichloromethane / 18 h / 20 °C

2.1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / Cooling with ice

3.1: triethylamine / ethanol / 8 h / 90 °C

3.2: 3 h / 20 °C

4.1: pyridine / 4 h / 20 °C

5.1: hydrogen; triethylamine / palladium 10% on activated carbon / methanol / 4 h

6.1: trifluoroacetic anhydride / pyridine

7.1: 4,5-dicyano-1H-imidazole / dichloromethane

With 4,5-dicyano-1H-imidazole; di-isopropyl azodicarboxylate; hydrogen; triethylamine; triphenylphosphine; trifluoroacetic anhydride; palladium 10% on activated carbon; In pyridine; methanol; ethanol; dichloromethane;