[1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

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Chemical Name:[1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester
CAS No.:1403740-79-3
Molecular Formula:C₃₁H₃₆ClN₃O₆
Molecular Weight:582.096
Hs Code.:

Synonyms:[1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

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Chemical Property of [1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

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Technology Process of [1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

There total 6 articles about [1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1403740-78-2
[1-(4-chloro-phenyl)-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

: 75-03-6
ethyl iodide

: 1403740-79-3
[1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: [1-(4-chloro-phenyl)-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.25h;

ethyl iodide; In tetrahydrofuran; at 20 ℃; for 0.25h;

Reference yield:

: 16013-85-7,136901-10-5
2,6-dicholoro-3-nitropyridine

: 1403740-79-3
[1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydride / 1,4-dioxane; oil / 6 h / 10 - 20 °C

2.1: triethylamine / acetonitrile / 16 h / 10 - 20 °C

3.1: hydrogen; acetic acid / palladium-on-charcoal / ethanol / 24 h

4.1: cesium fluoride; N,N`-dimethylethylenediamine / copper(l) iodide / acetonitrile / 16 h / 80 °C / Inert atmosphere

5.1: dmap / 1,4-dioxane / 8 h / 100 °C

5.2: 2 h

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

6.2: 0.25 h / 20 °C

With dmap; hydrogen; sodium hydride; acetic acid; triethylamine; cesium fluoride; lithium hexamethyldisilazane; N,N`-dimethylethylenediamine; copper(l) iodide; palladium-on-charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; acetonitrile; oil;

Reference yield:

: 1403740-69-1
[6-(2,4-dimethoxy-benzylamino)-3-nitro-pyridin-2-yloxy]acetic acid ethyl ester

: 1403740-79-3
[1-(4-chloro-phenyl)-3,3-diethyl-2-oxo-2,3-dihydro-1H-pyrido[2,3-b][1,4]oxazin-6-yl]-(2,4-dimethoxy-benzyl)-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrogen; acetic acid / palladium-on-charcoal / ethanol / 24 h

2.1: cesium fluoride; N,N`-dimethylethylenediamine / copper(l) iodide / acetonitrile / 16 h / 80 °C / Inert atmosphere

3.1: dmap / 1,4-dioxane / 8 h / 100 °C

3.2: 2 h

4.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / -78 °C

4.2: 0.25 h / 20 °C

With dmap; hydrogen; acetic acid; cesium fluoride; lithium hexamethyldisilazane; N,N`-dimethylethylenediamine; copper(l) iodide; palladium-on-charcoal; In tetrahydrofuran; 1,4-dioxane; ethanol; acetonitrile;