5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid

Base Information

Chemical Name:5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid
CAS No.:1415129-75-7
Molecular Formula:C₂₆H₂₀Cl₂N₂O₂
Molecular Weight:463.363
Hs Code.:

Synonyms:5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid

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Chemical Property of 5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid

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Technology Process of 5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid

There total 8 articles about 5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 29682-15-3
methyl 5-bromopicolinate

: 1415129-75-7
5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane; water / 16 h / 80 °C

2: dibenzoyl peroxide; N-Bromosuccinimide / benzene / 16 h / Reflux

3: potassium carbonate / acetone / 18 h / 50 °C

4: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With N-Bromosuccinimide; water; potassium carbonate; sodium hydroxide; dibenzoyl peroxide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; water; acetone; benzene;

Reference yield:

: 1415129-72-4
methyl 5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinate

: 1415129-75-7
5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid

Guidance literature:: methyl 5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 16h;

With hydrogenchloride; In water;

Reference yield:

: 1679-18-1
4-Chlorophenylboronic acid

: 1415129-75-7
5-(5-chloro-2-(((4'-chloro-[1,1'-biphenyl]-4-yl)(methyl)amino)methyl)phenyl)picolinic acid

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane; water / 16 h / 80 °C

2: potassium carbonate / acetone / 18 h / 50 °C

3: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 20 °C

With water; potassium carbonate; sodium hydroxide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; water; acetone;