3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal

Base Information

• Chemical Name: 3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal
• CAS No.: 935681-46-2
• Molecular Formula: C₃₃H₃₆O₄Si
• Molecular Weight: 524.732
• Mol file: 935681-46-2.mol

Synonyms:3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal

Chemical Property of 3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal

There total 1 articles about 3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

3-(O-(tert-butyldiphenylsilyl)hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol (935681-44-0) + 2,2-dimethoxy-propane (77-76-9) → 3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal (935681-46-2)

Guidance literature:

With toluene-4-sulfonic acid; sodium sulfate; In acetone; at 40 ℃; for 72h;

DOI:10.1021/jm0611713

Reference yield: 89.0%

3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal (935681-46-2) → C17H18O4 (935681-52-0)

Guidance literature:

With ammonium fluoride; In methanol; at 20 ℃; for 61h;

DOI:10.1021/jm0611713

Reference yield:

3-(O(-tert-butyldiphenylsilyl)-hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol-2',3'-O-isopropylideneacetal (935681-46-2) → N,N-diisopropyl-7-phenyl-2,3-dihydro-1,2-benzoxaphosphol-2-amine-2-oxide

Guidance literature:

Multi-step reaction with 3 steps

1.1: 89 percent / NH₄F / methanol / 61 h / 20 °C

2.1: PCl₃ / diethyl ether / 0.17 h / -40 °C

2.2: 696 mg / pyridine / diethyl ether / 2 h / -40 - 20 °C

3.1: DIPEA / acetonitrile / 6 h / -20 - 20 °C

3.2: 192 mg / tert-butyl hydroperoxide / acetonitrile; decane / 1 h / -20 - 20 °C

With ammonium fluoride; N-ethyl-N,N-diisopropylamine; phosphorus trichloride; In methanol; diethyl ether; acetonitrile;

DOI:10.1021/jm0611713

upstream raw materials:

3-(O-(tert-butyldiphenylsilyl)hydroxymethyl)-3'-(hydroxymethyl)biphenyl-2,2'-diol

2,2-dimethoxy-propane

Downstream raw materials:

C₁₇H₁₈O₄