2,4-DICHLORO-6,7-DIFLUOROQUINAZOLINE

Base Information

• Chemical Name: 2,4-DICHLORO-6,7-DIFLUOROQUINAZOLINE
• CAS No.: 774212-69-0
• Molecular Formula: C8H2 Cl2 F2 N2
• Molecular Weight: 235.02
• Mol file: 774212-69-0.mol

Synonyms:2,4-Dichloro-6,7-difluoroquinazoline

Chemical Property of 2,4-DICHLORO-6,7-DIFLUOROQUINAZOLINE

Chemical Property:

• PSA: 25.78000
• LogP: 3.21480

Purity/Quality:

≥95% ^*data from raw suppliers

2,4-Dichloro-6,7-difluoroquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-DICHLORO-6,7-DIFLUOROQUINAZOLINE

There total 5 articles about 2,4-DICHLORO-6,7-DIFLUOROQUINAZOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

6,7-difluoroquinazoline-2,4(1H,3H)-dione (769158-54-5) → 2,4-dichloro-6,7-difluoroquinazoline (774212-69-0)

Guidance literature:

With N,N-dimethyl-aniline; trichlorophosphate; at 120 ℃; for 7h; Heating / reflux;

Reference yield:

2-amino-4,5-difluorobenzoic acid (83506-93-8) → 2,4-dichloro-6,7-difluoroquinazoline (774212-69-0)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 h / 160 °C

2: trichlorophosphate / 115 °C

With trichlorophosphate;

Reference yield:

2-amino-4,5-difluoro-benzoic acid,methyl ester (207346-42-7) → 2,4-dichloro-6,7-difluoroquinazoline (774212-69-0)

Guidance literature:

Multi-step reaction with 3 steps

1.1: acetic acid / water / 22 h / 20 - 60 °C

2.1: sodium hydroxide / methanol; water / 20 h / 20 °C

3.1: trichlorophosphate / toluene / 0.17 h / 20 °C

3.2: 4 h / 55 - 105 °C

With acetic acid; sodium hydroxide; trichlorophosphate; In methanol; water; toluene;

upstream raw materials:

6,7-difluoroquinazoline-2,4(1H,3H)-dione

2-amino-4,5-difluorobenzoic acid

2-amino-4,5-difluoro-benzoic acid,methyl ester

Refernces

• 1、 -. "INHIBITORS OF INFLUENZA VIRUS REPLICATION, APPLICATION METHODS AND USES THEREOF". Paragraph 00414. . Retrieved 2018/03/09.
• 2、 -. "NOVEL QUINAZOLINE DERIVATIVES AND METHODS OF TREATMENT RELATED TO THE USE THEREOF". Page 166-167. . Retrieved 2010/02/08.