2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide

Base Information

• Chemical Name: 2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide
• CAS No.: 40531-95-1
• Molecular Formula: C₁₀H₁₀ClNOS
• Molecular Weight: 227.714
• Mol file: 40531-95-1.mol

Synonyms:2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide

Chemical Property of 2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide

There total 4 articles about 2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone (4996-21-8) + dimethyl amine (124-40-3) → 2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide (40531-95-1)

Guidance literature:

With sulfur; sodium sulfide; In water; at 60 ℃;

DOI:10.1080/17415993.2014.955026

Reference yield: 77.0%

3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one (28587-05-5) → 2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide (40531-95-1)

Guidance literature:

With sulfur; dmap; In N,N-dimethyl-formamide; at 90 ℃; for 24h;

DOI:10.1021/acs.joc.8b02670

Reference yield:

para-chloroacetophenone (99-91-2) → 2-(4-chlorophenyl)-N,N-dimethyl-2-oxoethanethioamide (40531-95-1)

Guidance literature:

Multi-step reaction with 2 steps

1: selenium(IV) oxide / 1,4-dioxane; water / 6 h / Reflux

2: sulfur; sodium sulfide / water / 60 °C

With sulfur; sodium sulfide; selenium(IV) oxide; In 1,4-dioxane; water; 2: |Willgerodt-Kindler Rearrangement;

DOI:10.1080/17415993.2014.955026

upstream raw materials:

para-chloroacetophenone

dimethyl amine

1-(4-chloro-phenyl)-2,2-dihydroxy-ethanone

3-dimethylamino-1(4-chloro-phenyl)-2-propen-1-one

Downstream raw materials:

2-(4-chlorophenyl)-N,N-dimethylethanethioamide

C₁₀H₁₂ClNOS

2-(4-chlorophenyl)-N,N-dimethyl-2-thioethane-thioamide