(+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Base Information

Chemical Name:(+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate
CAS No.:1187645-93-7
Molecular Formula:C₃₀H₂₄Cl₂N₈O₃
Molecular Weight:615.478
Hs Code.:

Synonyms:(+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Suppliers and Price of (+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

There total 7 articles about (+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.1%

: 1094107-15-9
2,5-dioxopyrrolidin-1-yl (2E)-3-[5-chloro-2-(1H-1,2,3,4-tetrazol-1-yl)phenyl]prop-2-enoate

: methyl 4-(5-(1-amino-2-phenylethyl)-6-chloropyridazin-3-yl)phenylcarbamate trifluoroacetate

: 1187645-93-7
(+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 1187648-11-8
2-(1-(3,6-dichloropyridazin-4-yl)-2-phenylethyl)isoindoline-1,3-dione

: 1187645-93-7
(+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 3 steps

1: potassium phosphate / triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

2: hydrazine / ethanol / 4 h / 80 °C

3: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With potassium phosphate; N-ethyl-N,N-diisopropylamine; hydrazine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; ethanol; N,N-dimethyl-formamide; 1: Suzuki Coupling;

Reference yield:

: 5123-55-7
Nα-phthaloyl-L-phenylalanine

: 1187645-93-7
(+/-)-(E)-methyl 4-(6-chloro-5-(1-(3-(5-chloro-2-(1H-tetrazol-1-yl)phenyl)acrylamido)-2-phenylethyl)pyridazin-3-yl)phenylcarbamate

Guidance literature:: Multi-step reaction with 4 steps

1: ammonium peroxydisulfate; silver nitrate; trifluoroacetic acid / water / 0.83 h / 70 °C

2: potassium phosphate / triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾ / 1,4-dioxane / 2 h / 90 °C / Inert atmosphere

3: hydrazine / ethanol / 4 h / 80 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 24 h / 20 °C

With ammonium peroxydisulfate; potassium phosphate; silver nitrate; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; hydrazine; triphenylphosphine; bis(dibenzylideneacetone)-palladium⁽⁰⁾; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide; 2: Suzuki Coupling;