N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide

Base Information

Chemical Name:N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide
CAS No.:1426094-95-2
Molecular Formula:C₂₄H₂₈N₂O₃
Molecular Weight:392.498
Hs Code.:

Synonyms:N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide

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Chemical Property of N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide

Chemical Property:

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Technology Process of N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide

There total 11 articles about N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1426095-69-3
N-methyl-3-(methyloxy)-N-(3(RS)-pyrrolidinylmethyl)-4-biphenylcarboxamide

: 4023-34-1
cyclopropanecarboxylic acid chloride

: 1426094-95-2
N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide

Guidance literature:: With triethylamine; In tetrahydrofuran; for 0.25h;

Reference yield:

: 270912-72-6
tert-butyl 3-(aminomethyl)pyrrolidine-1-carboxylate

: 1426094-95-2
N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h

2.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h

2.2: 18 h

3.1: hydrogenchloride / tetrahydrofuran; water / 0.17 h

3.2: pH 7

4.1: triethylamine / tetrahydrofuran / 0.25 h

With hydrogenchloride; triethylamine; HATU; lithium hexamethyldisilazane; In tetrahydrofuran; water; N,N-dimethyl-formamide;

Reference yield:

: 93138-61-5
C-(1-benzyl-pyrrolidin-3-yl)-methylamine

: 1426094-95-2
N-{[1-cyclopropylcarbonyl-3(RS)-pyrrolidinyl]methyl}-N-methyl-3-(methyloxy)-4-biphenylcarboxamide

Guidance literature:: Multi-step reaction with 8 steps

1.1: dichloromethane / 12 h / 0 - 20 °C

2.1: palladium 10% on activated carbon; hydrogen; palladium(II) hydroxide; acetic acid / methanol / 48 h / 20 °C

3.1: triethylamine / methanol / 0.5 h / 0 °C

3.2: 24 h / 0 - 20 °C

4.1: sodium hydroxide / methanol; water / 3 h / 20 °C

5.1: triethylamine; HATU / N,N-dimethyl-formamide / 18 h

6.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.17 h

6.2: 18 h

7.1: hydrogenchloride / tetrahydrofuran; water / 0.17 h

7.2: pH 7

8.1: triethylamine / tetrahydrofuran / 0.25 h

With hydrogenchloride; palladium 10% on activated carbon; hydrogen; palladium(II) hydroxide; acetic acid; triethylamine; HATU; sodium hydroxide; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;