rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester
CAS No.:1313525-82-4
Molecular Formula:C₁₅H₂₂BrFN₂O₂
Molecular Weight:361.254
Hs Code.:

Synonyms:rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester

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Chemical Property of rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester

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Technology Process of rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester

There total 11 articles about rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1313525-82-4
rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester

Guidance literature:

Reference yield:

: 198477-89-3
1-(5-bromo-2-fluorophenyl)ethan-1-one

: 1313525-82-4
rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 8 steps

1.1: ammonium hydroxide; ammonium chloride / water / 20 °C

1.2: Reflux

2.1: hydrogenchloride; water / Reflux

3.1: sodium hydroxide / water

4.1: dimethylsulfide borane complex / tetrahydrofuran / 5 h / Reflux

5.1: sodium hydrogencarbonate / 1,4-dioxane; water

6.1: thionyl chloride; pyridine / dichloromethane / 16 h / 0 - 25 °C

7.1: sodium periodate / rhodium(III) chloride hydrate / acetonitrile; water / 1 h / 0 - 25 °C

8.1: ethanol / 18 h / 25 °C

8.2: 1 h

With pyridine; hydrogenchloride; ammonium hydroxide; sodium periodate; thionyl chloride; dimethylsulfide borane complex; water; sodium hydrogencarbonate; ammonium chloride; sodium hydroxide; rhodium(III) chloride hydrate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;

Reference yield:

: 1266784-24-0
(RS)-2-amino-2-(5-bromo-2-fluoro-phenyl)-propan-1-ol

: 1313525-82-4
rac-[1-(5-bromo-2-fluoro-phenyl)-1-methyl-2-methyl-amino-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydrogencarbonate / 1,4-dioxane; water

2.1: thionyl chloride; pyridine / dichloromethane / 16 h / 0 - 25 °C

3.1: sodium periodate / rhodium(III) chloride hydrate / acetonitrile; water / 1 h / 0 - 25 °C

4.1: ethanol / 18 h / 25 °C

4.2: 1 h

With pyridine; sodium periodate; thionyl chloride; sodium hydrogencarbonate; rhodium(III) chloride hydrate; In 1,4-dioxane; ethanol; dichloromethane; water; acetonitrile;