4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone

Base Information

• Chemical Name: 4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone
• CAS No.: 75088-20-9
• Molecular Formula: C₂₇H₃₂O₈
• Molecular Weight: 484.546
• Mol file: 75088-20-9.mol

Synonyms:4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone

Chemical Property of 4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone

There total 4 articles about 4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl bromoacetate (105-36-2) + 4-hydroxy-2'-methoxycarboxymethoxy-4'-(3-methyl-2-butenyloxy)dihydrochalcone (75088-19-6) → 4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone (75088-20-9)

Guidance literature:

With potassium carbonate; In acetone; for 2h; Heating;

DOI:10.1248/cpb.33.1327

Reference yield:

sofalcone (64506-49-6) → 4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone (75088-20-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 71 percent / concd. HCl / 2 h / Heating

2: 82 percent / H₂ / Pd-C (10percent) / methanol

3: 70 percent / K₂CO₃ / acetone / 4 h / Ambient temperature

4: 90 percent / K₂CO₃ / acetone / 2 h / Heating

With hydrogenchloride; hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; acetone;

DOI:10.1248/cpb.33.1327

Reference yield:

4,4'-dihydroxy-2'-methoxycarbonylmethoxychalcone (75088-15-2) → 4-ethoxycarbonylmethoxy-2'-(methoxycarbonylmethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone (75088-20-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 82 percent / H₂ / Pd-C (10percent) / methanol

2: 70 percent / K₂CO₃ / acetone / 4 h / Ambient temperature

3: 90 percent / K₂CO₃ / acetone / 2 h / Heating

With hydrogen; potassium carbonate; palladium on activated charcoal; In methanol; acetone;

DOI:10.1248/cpb.33.1327

upstream raw materials:

ethyl bromoacetate

4-hydroxy-2'-methoxycarboxymethoxy-4'-(3-methyl-2-butenyloxy)dihydrochalcone

sofalcone

4,4'-dihydroxy-2'-(methoxycarbonylmethoxy)dihydrochalcone

Downstream raw materials:

2',4-bis(carboxymethoxy)-4'-(3-methyl-2-butenyloxy)dihydrochalcone

Refernces