3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one

Base Information

Chemical Name:3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one
CAS No.:1620951-89-4
Molecular Formula:C₃₂H₃₂N₄O₄S
Molecular Weight:568.696
Hs Code.:

Synonyms:3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one

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Chemical Property of 3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one

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Technology Process of 3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one

There total 10 articles about 3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.6%

: 1620955-35-2
C₃₁H₃₄N₄O₄

: 88681-68-9
di(1H-imidazol-2-yl)methanethione

: 1620951-89-4
3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 1620955-33-0
C₂₉H₃₁N₃O₃

: 1620951-89-4
3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 72 h / 0 - 20 °C / Inert atmosphere

2: piperidine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

3: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With piperidine; triethylamine; N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1620955-34-1
C₄₆H₄₄N₄O₆

: 1620951-89-4
3-(2-(4'-(4-((tetrahydro-2H-pyran-2-yl)oxy)butoxy)-[1,1'-biphenyl]-4-yl)-1,6-naphthyridin-4-yl)-2-thioxoimidazolidin-4-one

Guidance literature:: Multi-step reaction with 2 steps

1: piperidine / N,N-dimethyl-formamide / 0.5 h / 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C / Inert atmosphere

With piperidine; triethylamine; In dichloromethane; N,N-dimethyl-formamide;