(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

Base Information

Chemical Name:(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide
CAS No.:1497427-33-4
Molecular Formula:C₂₀H₂₈FN₃O₄
Molecular Weight:393.458
Hs Code.:

Synonyms:(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

Suppliers and Price of (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

Chemical Property:

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Technology Process of (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

There total 5 articles about (S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 142-61-0
Hexanoyl chloride

: 168828-90-8
(S)-N-[[3-[3-fluoro-4-[4-morpholinyl]phenyl]-2-oxo-5-oxazolidinyl]methyl]amine

: 1497427-33-4
(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

Guidance literature:: With triethylamine; In toluene; at 0 - 20 ℃; for 3h;
DOI:10.13005/ojc/290322

Reference yield:

: 93246-53-8
3-fluoro-4-(morpholinyl)aniline

: 1497427-33-4
(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

Guidance literature:: Multi-step reaction with 5 steps

1: methanol / 16 h / Reflux

2: dichloromethane / 20 h / 20 °C

3: N,N-dimethyl-formamide / 5 h / Reflux

4: hydrazine hydrate / methanol / 1 h / Reflux

5: triethylamine / toluene / 3 h / 0 - 20 °C

With hydrazine hydrate; triethylamine; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene;
DOI:10.13005/ojc/290322

Reference yield:

: (5R)-5-(chloromethyl)-3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxazolidinone

: 1497427-33-4
(S)-N-[[3-[3-fluoro-4-morpholinophenyl]-2-oxo-5-oxazolidinyl]methyl]hexanamide

Guidance literature:: Multi-step reaction with 3 steps

1: N,N-dimethyl-formamide / 5 h / Reflux

2: hydrazine hydrate / methanol / 1 h / Reflux

3: triethylamine / toluene / 3 h / 0 - 20 °C

With hydrazine hydrate; triethylamine; In methanol; N,N-dimethyl-formamide; toluene;
DOI:10.13005/ojc/290322