dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate

Base Information

• Chemical Name: dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate
• CAS No.: 1332367-79-9
• Molecular Formula: C₃₂H₃₄N₄O₄
• Molecular Weight: 538.646
• Mol file: 1332367-79-9.mol

Synonyms:dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate

Chemical Property of dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate

There total 7 articles about dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

methyl 6-(bromomethyl)picolinate (146462-25-1) + N,N'-Dibenzylethylenediamine (140-28-3,87170-83-0) → dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate (1332367-79-9)

Guidance literature:

With alkali metal carbonate; In acetonitrile; at 60 ℃;

DOI:10.1016/j.bioorg.2020.103965

Reference yield: 57.0%

N,N'-dibenzylethylenediamine dihydrochloride (3412-76-8,63674-12-4) + methyl 6-(bromomethyl)picolinate (146462-25-1) → dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate (1332367-79-9)

Guidance literature:

With potassium carbonate; In acetonitrile; for 72h; Reflux;

DOI:10.1021/acs.inorgchem.0c00671

Reference yield: 46.0%

→ dimethyl 6,6′([ethane-1,2-diylbis{benzylazanediyl}]bis[methylene])dipicolinate (1332367-79-9)

Guidance literature:

upstream raw materials:

methyl 6-(hydroxymethyl)pyridine-2-carboxylate

methyl 6-(bromomethyl)picolinate

N,N'-Dibenzylethylenediamine

benzaldehyde

Downstream raw materials:

6,6'-((ethane-1,2-diylbis(benzylazanediyl))bis(methylene))dipicolinic acid

Refernces

• 1、 Bai, Meng-Meng,Cui, De-Yun,Han, Jiang-Xue,Kong, Hong-Tao,Liu, Yi-Shuang,Shen, Bo-Yuan,Wang, Cong-Cong,Xiao, Chun-Ling,Yan, Da-Chao,Yang, Yi,Zhang, En. "Systematic research of H2dedpa derivatives as potent inhibitors of New Delhi Metallo-β-lactamase-1". . . Retrieved 2020/06/01.