tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate

Base Information

• Chemical Name: tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate
• CAS No.: 206273-84-9
• Molecular Formula: C₁₈H₂₈N₂O₃
• Molecular Weight: 320.432
• Mol file: 206273-84-9.mol

Synonyms:tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate

Chemical Property of tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate

Chemical Property:

• Boiling Point: 433.3±40.0 °C(Predicted)
• PKA: 9.59±0.20(Predicted)
• Density: 1.09±0.1 g/cm3(Predicted)

Purity/Quality:

99% ^*data from raw suppliers

tert-Butyl4-(4-methoxybenzylamino)piperidine-1-carboxylate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate

There total 2 articles about tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

1-bromo-4-methoxy-benzene (104-92-7) + 1-[(tert-butoxy)carbonyl]-N-[(trifluoro-λ4-boranyl)methyl]piperidin-4-aminium → tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate (206273-84-9)

Guidance literature:

With chloro[(tri-tert-butylphosphine)-2-(2-aminobiphenyl)]palladium (II); caesium carbonate; In tetrahydrofuran; water; at 60 ℃; for 24h; Inert atmosphere;

DOI:10.1002/chem.201200831

Reference yield:

1-(tert-butoxycarbonyl)-4-aminopiperidine (87120-72-7) + 4-methoxy-benzaldehyde (123-11-5) → tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate (206273-84-9)

Guidance literature:

With sodium tris(acetoxy)borohydride; acetic acid; In 1,2-dichloro-ethane; at 20 ℃;

DOI:10.1016/j.bmcl.2016.04.086

Reference yield: 23.0%

tert-butyl 4-(4-methoxybenzylamino)piperidine-1-carboxylate (206273-84-9) + 2',4,6-trichloro-N'-tosylbiphenyl-3-carbohydrazonoyl chloride → tert-butyl 4-((6-chloro-5-(2-chlorophenyl)-1-tosyl-1H-indazol-3-yl)(4-methoxybenzyl)amino) piperidine-1-carboxylate

Guidance literature:

With potassium carbonate; In 1-methyl-pyrrolidin-2-one; at 40 ℃;

upstream raw materials:

1-bromo-4-methoxy-benzene

1-(tert-butoxycarbonyl)-4-aminopiperidine

4-methoxy-benzaldehyde

Downstream raw materials:

(R)-2-cyclopentylmethyl-3-(formyl-hydroxy-amino)-N-{(S)-1-[4-(4-methoxy-benzylamino)-piperidine-1-carbonyl]-2,2-dimethyl-propyl}-propionamide

[1-((S)-2-amino-3,3-dimethyl-butyryl)-piperidin-4-yl]-(4-methoxy-benzyl)-carbamic acid benzyl ester hydrochloride

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