[[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone

Base Information

Chemical Name:[[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone
CAS No.:1258203-01-8
Molecular Formula:C₂₀H₂₆BrN₃OSSi
Molecular Weight:464.501
Hs Code.:

Synonyms:[[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone

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Chemical Property of [[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone

Chemical Property:

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Technology Process of [[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone

There total 8 articles about [[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

: 1258203-31-4
[3-(t-butyldimethylsilyl)oxyphenyl]-(3-bromophenyl)methanone

: 79-19-6
thiosemicarbazide

: 1258203-01-8
[[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone

Guidance literature:: With toluene-4-sulfonic acid; In methanol; at 70 ℃; for 8h; Inert atmosphere;
DOI:10.1016/j.bmcl.2010.09.026

Reference yield:

: 18162-48-6
tert-butyldimethylsilyl chloride

: 1258203-01-8
[[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone

Guidance literature:: Multi-step reaction with 4 steps

1.1: 1H-imidazole / N,N-dimethyl-formamide / 6 h / 20 °C

2.1: magnesium; iodine / diethyl ether / 2.5 h / 20 - 30 °C / Inert atmosphere

2.2: 8 h / 0 - 20 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 3 h / 0 - 20 °C / Inert atmosphere

4.1: toluene-4-sulfonic acid / methanol / 8 h / 70 °C

With 1H-imidazole; iodine; toluene-4-sulfonic acid; magnesium; pyridinium chlorochromate; In methanol; diethyl ether; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2012.10.039

Reference yield:

: 65423-56-5
1-bromo-3-[(tert-butyldimethylsilyl)oxy]benzene

: 1258203-01-8
[[3-(t-butyldimethylsilyl)oxyphenyl](3-bromophenyl)ketone]thiosemicarbazone

Guidance literature:: Multi-step reaction with 2 steps

1.1: n-butyllithium / tetrahydrofuran / 1.33 h / -78 °C

1.2: 2 h / -78 °C

2.1: toluene-4-sulfonic acid / methanol / 9 h / Inert atmosphere; Reflux

With n-butyllithium; toluene-4-sulfonic acid; In tetrahydrofuran; methanol;