N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Base Information

Chemical Name:N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide
CAS No.:1227263-95-7
Molecular Formula:C₃₃H₃₆N₆O₄S
Molecular Weight:612.753
Hs Code.:

Synonyms:N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

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Chemical Property of N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

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Technology Process of N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

There total 8 articles about N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 225520-11-6
2-amino-N-mesitylbenzo[d]thiazole-6-carboxamide

: 196195-13-8
4-(3-((4-chloro-6-methoxyquinazolin-7-yl)oxy)propyl)morpholine

: 1227263-95-7
N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Guidance literature:: 2-amino-N-mesitylbenzo[d]thiazole-6-carboxamide; With sodium hydride; In tetrahydrofuran; at 20 ℃; for 3h;

4-(3-((4-chloro-6-methoxyquinazolin-7-yl)oxy)propyl)morpholine; In tetrahydrofuran; at 20 ℃; for 12h;
DOI:10.1016/j.ejmech.2013.03.013

Reference yield:

: 3943-74-6
4-hydroxy-3-methoxybenzoic acid methyl ester

: 1227263-95-7
N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 70 °C

2.1: nitric acid / acetic acid; ethyl acetate / 2.5 h / 0 - 55 °C

3.1: iron / acetic acid; ethyl acetate / 6 h / 75 °C / Inert atmosphere

4.1: ethanol / 6 h / Reflux

5.1: potassium iodide / N,N-dimethyl-formamide / 6 h / 70 °C

6.1: N,N-dimethyl-formamide; thionyl chloride / 1 h / Reflux

7.1: sodium hydride / tetrahydrofuran / 3 h / 20 °C

7.2: 12 h / 20 °C

With thionyl chloride; nitric acid; iron; sodium hydride; potassium carbonate; N,N-dimethyl-formamide; potassium iodide; In tetrahydrofuran; ethanol; acetic acid; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/j.ejmech.2013.03.013

Reference yield:

: 225520-10-5
tert-butyl 6-(mesitylcarbamoyl)benzo[d]thiazol-2-yl-carbamate

: 1227263-95-7
N-mesityl-2-(6-methoxy-7-(3-morpholinopropoxy)quinazolin-4-ylamino)benzo[d]thiazole-6-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

2.1: sodium hydride / tetrahydrofuran / 3 h / 20 °C

2.2: 12 h / 20 °C

With sodium hydride; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.ejmech.2013.03.013