[benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester

Base Information

• Chemical Name: [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester
• CAS No.: 1384745-30-5
• Molecular Formula: C₂₁H₂₆ClNO₂
• Molecular Weight: 359.896
• Mol file: 1384745-30-5.mol

Synonyms:[benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester

Chemical Property of [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester

There total 3 articles about [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

[benzyl-(2-hydroxyethyl)-amino]-phenyl-acetic acid tert-butyl ester (1384745-27-0) → [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester (1384745-30-5)

Guidance literature:

[benzyl-(2-hydroxyethyl)-amino]-phenyl-acetic acid tert-butyl ester; With thionyl chloride; In dichloromethane; for 2h; Reflux; Inert atmosphere;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; Inert atmosphere;

DOI:10.1016/j.tetasy.2012.05.006

Reference yield:

tert-butyl α-bromo-α-phenylacetate (35132-16-2) → [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester (1384745-30-5)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium carbonate; sodium iodide / acetonitrile / Reflux; Inert atmosphere

2.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

2.2: 0 °C / Inert atmosphere

With thionyl chloride; potassium carbonate; sodium iodide; In dichloromethane; acetonitrile;

DOI:10.1016/j.tetasy.2012.05.006

Reference yield:

bromo(phenyl)acetyl chloride (19078-72-9) → [benzyl-(2-chloroethyl)-amino]-phenyl-acetic acid tert-butyl ester (1384745-30-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: pyridine / diethyl ether / Inert atmosphere

2.1: potassium carbonate; sodium iodide / acetonitrile / Reflux; Inert atmosphere

3.1: thionyl chloride / dichloromethane / 2 h / Reflux; Inert atmosphere

3.2: 0 °C / Inert atmosphere

With pyridine; thionyl chloride; potassium carbonate; sodium iodide; In diethyl ether; dichloromethane; acetonitrile;

DOI:10.1016/j.tetasy.2012.05.006

upstream raw materials:

[benzyl-(2-hydroxyethyl)-amino]-phenyl-acetic acid tert-butyl ester

bromo(phenyl)acetyl chloride

tert-butyl α-bromo-α-phenylacetate

Downstream raw materials:

1-benzyl-2-phenyl-azetidine-2-carboxylic acid tert-butyl ester