methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate

Base Information

Chemical Name:methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate
CAS No.:680218-13-7
Molecular Formula:C₁₆H₃₀O₄
Molecular Weight:286.412
Hs Code.:

Synonyms:methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate

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Technology Process of methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate

There total 4 articles about methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 75-07-0,9002-91-9
acetaldehyde

: 680218-11-5
methyl 4-[(1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl]butanoate

: 680218-13-7
methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate

Guidance literature:: With N,N,N,N,N,N-hexamethylphosphoric triamide; lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 2.5h;
DOI:10.1081/SCC-120027252

Reference yield:

: 60134-39-6
(-)-(4aS,8aS)-3,4,4a,5,6,7,8,8a-octahydro-5,5,8a-trimethylnaphthalen-1(2H)-one

: 680218-13-7
methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 4 steps

1: 93 percent / m-chloroperoxybenzoic acid; NaHCO₃ / CH₂Cl₂ / 1.5 h / 20 °C

2: sodium hydroxide / ethanol; H₂O / 2.3 h / 20 °C

3: 97 mg / diethyl ether / 0 °C

4: 74 percent / lithium diisopropylamide; hexamethylphosphoramide / tetrahydrofuran / 2.5 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; dichloromethane; water; 1: Baeyer-Villiger reaction / 4: aldol condensation;
DOI:10.1081/SCC-120027252

Reference yield:

: 217467-50-0
(1S,7S)-1,8,8-trimethyl-2-oxabicyclo[5.4.0]undecan-3-one

: 680218-13-7
methyl 2-[2-((1S,2S)-2-hydroxy-2,6,6-trimethylcyclohexyl)ethyl]-3-hydroxybutanoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / ethanol; H₂O / 2.3 h / 20 °C

2: 97 mg / diethyl ether / 0 °C

3: 74 percent / lithium diisopropylamide; hexamethylphosphoramide / tetrahydrofuran / 2.5 h / -78 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydroxide; lithium diisopropyl amide; In tetrahydrofuran; diethyl ether; ethanol; water; 3: aldol condensation;
DOI:10.1081/SCC-120027252