methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

Base Information

Chemical Name:methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate
CAS No.:1346134-56-2
Molecular Formula:C₄₃H₄₃N₃O₈S₂
Molecular Weight:793.962
Hs Code.:

methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

Synonyms:methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

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Chemical Property of methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

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Technology Process of methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

There total 10 articles about methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-30-9
2-iodo-propane

: 1346136-60-4
methyl 4-({[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

: 1346134-56-2
methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 80 ℃;

Reference yield:

: 4025-64-3
3-Carboxybenzenesulfonyl chloride

: 1346134-56-2
methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / 20 °C

2.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

2.2: 20 °C

3.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With pyridine; oxalyl dichloride; potassium carbonate; N,N-dimethyl-formamide; In dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 2609-49-6
diethyl p-nitrobenzylphosphonate

: 1346134-56-2
methyl 4-(isopropyl{[3-({3-[(4-{2-[4-(methoxycarbonyl)phenyl]ethyl}phenyl)carbamoyl]-4,5,6,7-tetrahydro-1-benzothiophen-2-yl}carbamoyl)phenyl]sulfonyl}amino)benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sodium methylate / methanol / 16 h / 20 °C / Cooling with ice

2.1: palladium 10% on activated carbon; hydrogen / tetrahydrofuran; N,N-dimethyl-formamide; water / 8 h / 20 °C / 760.05 Torr

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 24 h / 20 °C

4.1: morpholine / toluene / 4 h / 120 °C / Reflux; Dean-Stark

5.1: sulfur; morpholine / N,N-dimethyl-formamide / 1 h / 50 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane / 2 h / 20 °C

6.2: 20 °C

7.1: potassium carbonate / N,N-dimethyl-formamide / 80 °C

With morpholine; oxalyl dichloride; palladium 10% on activated carbon; hydrogen; sodium methylate; potassium carbonate; sulfur; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;