(R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

Base Information

Chemical Name:(R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine
CAS No.:1240299-85-7
Molecular Formula:C₂₆H₃₄F₃N₇O₂
Molecular Weight:533.597
Hs Code.:

Synonyms:(R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

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Chemical Property of (R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

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Technology Process of (R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

There total 7 articles about (R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13889-98-0
N-acetylpiperidine

: 1240300-31-5
1-(4-{1-[3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)propan-2-one

: 1240299-86-8
(S)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

: 1240299-85-7
(R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: N-acetylpiperidine; 1-(4-{1-[3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazin-6-yl]piperidin-4-yl}phenoxy)propan-2-one; With acetic acid; magnesium sulfate; In tetrahydrofuran; at 18 - 25 ℃; for 1h;

With sodium tris(acetoxy)borohydride; In tetrahydrofuran; for 16h;

In methanol; ethanol; 2-Methylpentane; Resolution of racemate;

Reference yield:

: 62614-84-0
4-(4-hydroxyphenyl)-1,2,3,6-tetrahydropiperidine

: 1240299-86-8
(S)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

: 1240299-85-7
(R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

2.1: hydrogen / 5%-palladium/activated carbon / methanol / 120 h / 50 °C / 3750.38 Torr

3.1: potassium carbonate / N,N-dimethyl acetamide / 2 h / 100 °C

4.1: acetic acid / magnesium sulfate / tetrahydrofuran / 1 h / 18 - 25 °C

4.2: 16 h

4.3: Merck 50 mm 20 μm Chiralcel OD column / Resolution of racemate

With hydrogen; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; 5%-palladium/activated carbon; magnesium sulfate; In tetrahydrofuran; methanol; N,N-dimethyl acetamide; N,N-dimethyl-formamide;

Reference yield:

: 19099-93-5
benzyl 4-oxo-1-piperidinecarboxylate

: 1240299-86-8
(S)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

: 1240299-85-7
(R)-6-(4-{4-[2-(4-acetylpiperazin-1-yl)propoxy]phenyl}piperidin-1-yl)-3-(trifluoromethyl)-7,8-dihydro[1,2,4]triazolo[4,3-b]pyridazine

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 2.5 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C

2.1: sodium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane; water / 1 h / 80 °C / Inert atmosphere

3.1: hydrogen / 5%-palladium/activated carbon / methanol / 2 h / 25 °C / 3750.38 Torr

4.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 1 h / 80 °C

5.1: hydrogen / 5%-palladium/activated carbon / methanol / 120 h / 50 °C / 3750.38 Torr

6.1: potassium carbonate / N,N-dimethyl acetamide / 2 h / 100 °C

7.1: acetic acid / magnesium sulfate / tetrahydrofuran / 1 h / 18 - 25 °C

7.2: 16 h

7.3: Merck 50 mm 20 μm Chiralcel OD column / Resolution of racemate

With hydrogen; sodium carbonate; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; lithium hexamethyldisilazane; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; 5%-palladium/activated carbon; magnesium sulfate; In tetrahydrofuran; 1,4-dioxane; methanol; N,N-dimethyl acetamide; water; N,N-dimethyl-formamide;