[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

Base Information

Chemical Name:[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate
CAS No.:1611455-04-9
Molecular Formula:C₂₂H₂₀Cl₂N₂O₅
Molecular Weight:463.317
Hs Code.:

Synonyms:[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

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Chemical Property of [(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

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Technology Process of [(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

There total 8 articles about [(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1611455-00-5
[(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-nitrobenzoate

: 1611455-04-9
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

Guidance literature:: With tin(II) chloride dihdyrate; In tetrahydrofuran; at 75 ℃; for 16h;

Reference yield:

: 120-14-9
3,4-dimethoxy-benzaldehyde

: 1611455-04-9
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium hexamethyldisilazane / tetrahydrofuran / 1 h / -78 °C / Inert atmosphere

1.2: -78 °C

2.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.1: methanol; chloroform / 2 h / 20 °C

4.1: potassium tert-butylate; methanol / toluene / 24 h / 20 °C

5.1: 3-chloro-benzenecarboperoxoic acid / ethyl acetate / 5 h / 20 °C

6.1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 20 °C

7.1: tin(II) chloride dihdyrate / tetrahydrofuran / 16 h / 75 °C

With methanol; dmap; tin(II) chloride dihdyrate; potassium tert-butylate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 3-chloro-benzenecarboperoxoic acid; lithium hexamethyldisilazane; In tetrahydrofuran; methanol; dichloromethane; chloroform; ethyl acetate; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1415994-42-1
(1S)-2-(3,5-dichloro-1-oxido-pyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethanol

: 1611455-04-9
[(1S)-2-(3,5-dichloro-1-oxidopyridin-1-ium-4-yl)-1-(3,4-dimethoxyphenyl)-ethyl] 3-aminobenzoate

Guidance literature:: Multi-step reaction with 2 steps

1: dmap; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 16 h / 20 °C

2: tin(II) chloride dihdyrate / tetrahydrofuran / 16 h / 75 °C

With dmap; tin(II) chloride dihdyrate; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In tetrahydrofuran; dichloromethane;