Technology Process of (3-Buten-1-yn-1-yldimethylsilyl)benzene
There total 7 articles about (3-Buten-1-yn-1-yldimethylsilyl)benzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
copper(l) iodide; tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
at 24 ℃;
for 13h;
Inert atmosphere;
Alkaline conditions;
DOI:10.1002/anie.202012027
- Guidance literature:
-
Multi-step reaction with 4 steps
1: Li / tetrahydrofuran / 18 h / 0 °C
2: 1.) diethylaluminium chloride / 1.) THF, 0 deg C, 10 min, 2.) THF, from -78 deg C to 0 deg C, 2 h
3: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, from -78 deg C to RT, 15 min
4: 1.) sodium hydride, BSA, 2.) dimethyl malonate / 2.) Pd(PPh3)4 / 1.) THF, 15 deg C, 5 min, 2.) THF, RT, 30 min
With
benzenesulfonamide; n-butyllithium; diethylaluminium chloride; lithium; sodium hydride; malonic acid dimethyl ester;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran;
DOI:10.1021/jo00263a042
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) diethylaluminium chloride / 1.) THF, 0 deg C, 10 min, 2.) THF, from -78 deg C to 0 deg C, 2 h
2: 1.) n-BuLi / 1.) THF, hexane, -78 deg C, 5 min, 2.) THF, hexane, from -78 deg C to RT, 15 min
3: 1.) sodium hydride, BSA, 2.) dimethyl malonate / 2.) Pd(PPh3)4 / 1.) THF, 15 deg C, 5 min, 2.) THF, RT, 30 min
With
benzenesulfonamide; n-butyllithium; diethylaluminium chloride; sodium hydride; malonic acid dimethyl ester;
tetrakis(triphenylphosphine) palladium(0);
DOI:10.1021/jo00263a042
