2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

Base Information

Chemical Name:2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine
CAS No.:120215-59-0
Molecular Formula:C₂₀H₂₈Cl₂N₄O₄
Molecular Weight:459.373
Hs Code.:

Synonyms:2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

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Technology Process of 2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

There total 3 articles about 2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 57101-48-1
p-hydroxyclonidine

: 120215-59-0
2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 63 percent / Heating

2: 79 percent / NaBH₄, LiCl / bis-(2-methoxy-ethyl) ether / 18 h / 50 °C

3: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 24 h

4: ethanol / 24 h

With sodium tetrahydroborate; sodium hydride; lithium chloride; In ethanol; diethylene glycol dimethyl ether;
DOI:10.1021/jm00115a008

Reference yield:

: 109988-71-8
2-<(4-hydroxy-2,6-dichlorophenyl)imino>-1,3-diacetylimidazolidine

: 120215-59-0
2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 24 h

2: ethanol / 24 h

With sodium hydride; In ethanol;
DOI:10.1021/jm00115a008

Reference yield:

: 109988-69-4
2-<<4-(acetyloxy)-2,6-dichlorophenyl>imino>-1,3-diacetylimidazolidine

: 120215-59-0
2-<<2,6-dichloro-4-<3-(tert-butylamino)-2-hydroxypropoxy>phenyl>imino>-1,3-diacetylimidazolidine

Guidance literature:: Multi-step reaction with 3 steps

1: 79 percent / NaBH₄, LiCl / bis-(2-methoxy-ethyl) ether / 18 h / 50 °C

2: 1.) NaH / 1.) DMF, 2 h, 2.) DMF, RT, 24 h

3: ethanol / 24 h

With sodium tetrahydroborate; sodium hydride; lithium chloride; In ethanol; diethylene glycol dimethyl ether;
DOI:10.1021/jm00115a008