N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide

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Chemical Name:N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide
CAS No.:1072027-24-7
Molecular Formula:C₂₅H₂₉FN₁₀O₂S₃
Molecular Weight:616.767
Hs Code.:

Synonyms:N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide

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Chemical Property of N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide

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Technology Process of N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide

There total 5 articles about N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

: 1072027-40-7
5-((S)-3-fluoro-pyrrolidin-1-yl)-4-piperazin-1-yl-7H-pyrrolo[2,3-d]pyrimidine

: 99845-39-3
N-(5-ethyl-[1,3,4]thiadiazol-2-yl)-4-isothiocyanato-benzenesulfonamide

: 1072027-24-7
N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide

Guidance literature:: With pyridine; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 1072027-36-1
4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazine-1-carboxylic acid tert-butyl ester

: 1072027-24-7
N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / isopropyl alcohol / 1 h / 150 °C / Microwave irradiation

2: trifluoroacetic acid; 1,3-Dimethoxybenzene / dichloromethane / 3 h / 0 - 20 °C

3: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; 1,3-Dimethoxybenzene; In dichloromethane; isopropyl alcohol;

Reference yield:

: 1072027-38-3
tert-butyl 4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carboxylate

: 1072027-24-7
N-[4-(5-ethyl-[1,3,4]thiadiazol-2-ylsulfamoyl)-phenyl]-4-[5-((S)-3-fluoro-pyrrolidin-1-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-piperazine-1-carbothioamide

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid; 1,3-Dimethoxybenzene / dichloromethane / 3 h / 0 - 20 °C

2: pyridine / dichloromethane / 16 h / 20 °C

With pyridine; trifluoroacetic acid; 1,3-Dimethoxybenzene; In dichloromethane;