EthanediaMide iMpurity F

Base Information

• Chemical Name: EthanediaMide iMpurity F
• CAS No.: 480452-37-7
• Molecular Formula: C₁₆H₂₂ClN₅O₃
• Molecular Weight: 367.835
• Mol file: 480452-37-7.mol

Synonyms:N¹-[(1S,2R,4S)-2-amino-4-[(dimethylamino)carbonyl]cyclohexyl]-N²-(5-chloro-2-pyridyl)ethanediamide

Chemical Property of EthanediaMide iMpurity F

Chemical Property:

• PKA: 9.46±0.70(Predicted)
• Density: 1.34±0.1 g/cm3(Predicted)

Purity/Quality:

97% ^*data from raw suppliers

Edoxabanimpurity6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Use Description: "EthanediaMide Impurity F" appears to be a chemical compound or impurity that might not have specific well-documented uses across different fields in the same way as some other compounds. In various industries, the role of such impurities or compounds may primarily involve quality control and analytical purposes. In the pharmaceutical sector, for instance, it might be essential for pharmaceutical manufacturers and researchers to identify and characterize impurities like "EthanediaMide Impurity F" to ensure product safety and efficacy. Analytical chemistry and quality assurance laboratories across industries could also use it as a reference material or standard to develop and validate analytical methods. In essence, the role of "EthanediaMide Impurity F" would largely center on maintaining quality standards and ensuring the purity of products in various fields where it may be encountered.

Technology Process of EthanediaMide iMpurity F

There total 11 articles about EthanediaMide iMpurity F which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]carbamic acid benzyl ester → N1-[(1S,2R,4S)-2-amino-4-[(dimethylamino)carbonyl]cyclohexyl]-N2-(5-chloro-2-pyridyl)ethanediamide (480452-37-7)

Guidance literature:

With formic acid; 5%-palladium/activated carbon; In tetrahydrofuran; at 20 - 30 ℃;

Reference yield: 90.0%

carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester (480452-36-6) → N1-[(1S,2R,4S)-2-amino-4-[(dimethylamino)carbonyl]cyclohexyl]-N2-(5-chloro-2-pyridyl)ethanediamide (480452-37-7)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 4h;

Reference yield:

(1R,2S,5S)-1-amino-4-(dimethylaminocarbonyl)-cyclohexyl-2-carbamic acid tert-butyl ester oxalate → N1-[(1S,2R,4S)-2-amino-4-[(dimethylamino)carbonyl]cyclohexyl]-N2-(5-chloro-2-pyridyl)ethanediamide (480452-37-7)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / acetonitrile; water / 10 - 60 °C

2: methanesulfonic acid / acetonitrile; water / 25 °C

With methanesulfonic acid; triethylamine; In water; acetonitrile;

upstream raw materials:

carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester

5-chloro-2-pyridylamine

(1S,2R,4S)-N₂-(tert-butoxycarbonyl)-4-(N,N-dimethylcarbamoyl)-1,2-cyclohexanediamine

ethyl 2-((5-chloropyridin -2-yl)amino)-2-oxoacetate

Downstream raw materials:

edoxaban

[14C]-Edoxaban tosylate