N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester

Base Information

• Chemical Name: N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester
• CAS No.: 349125-08-2
• Molecular Formula: C9H9ClN2O3
• Molecular Weight: 228.635
• Mol file: 349125-08-2.mol

Synonyms:N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester;EthanediaMide iMpurity C;Acetic acid, 2-[(5-chloro-2-pyridinyl)aMino]-2-oxo-, ethyl ester;Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate

Chemical Property of N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester

Chemical Property:

• PKA: 9.11±0.70(Predicted)
• PSA: 68.29000
• Density: 1.392±0.06 g/cm3(Predicted)
• LogP: 1.30960

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-((5-chloropyridin-2-yl)amino)-2-oxoacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester

There total 3 articles about N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

5-chloro-2-pyridylamine (1072-98-6) + Ethyl oxalyl chloride (4755-77-5) → ethyl 2-((5-chloropyridin -2-yl)amino)-2-oxoacetate (349125-08-2)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

5-chloro-2-pyridylamine (1072-98-6) → ethyl 2-((5-chloropyridin -2-yl)amino)-2-oxoacetate (349125-08-2)

Guidance literature:

Multi-step reaction with 2 steps

1: acetonitrile / 2 h / 50 °C

2: triethylamine

With triethylamine; In acetonitrile;

Reference yield:

[(5-chloropyridin-2-yl)amino]-2-glyoxylic acid ethyl ester monohydrochloride → ethyl 2-((5-chloropyridin -2-yl)amino)-2-oxoacetate (349125-08-2)

Guidance literature:

With triethylamine; Product distribution / selectivity;

upstream raw materials:

5-chloro-2-pyridylamine

Ethyl oxalyl chloride

Downstream raw materials:

2-((5-chloropyridin-2-yl)amino)-2-oxoacetic acid

[14C]-Edoxaban tosylate

edoxaban

carbamic acid, N-[(1R,2S,5S)-2-[[2-[(5-chloro-2-pyridinyl)amino]-2-oxoacetyl]amino]-5-[(dimethylamino)carbonyl]cyclohexyl]-1,1-dimethylethyl ester

Refernces

• 1、 Kobayakawa, Takuya,Konno, Kiju,Ohashi, Nami,Takahashi, Kohei,Masuda, Ami,Yoshimura, Kazuhisa,Harada, Shigeyoshi,Tamamura, Hirokazu. "Soluble-type small-molecule CD4 mimics as HIV entry inhibitors". supporting information. p. 719 - 723. Retrieved 2019/01/22.
• 2、 -. "PROCESS FOR PRODUCING DIAMINE DERIVATIVE". . . Retrieved 2012/02/04.