methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

Base Information

Chemical Name:methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate
CAS No.:921204-71-9
Molecular Formula:C₂₈H₃₅Cl₂FN₂O₃
Molecular Weight:537.502
Hs Code.:

Synonyms:methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

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Chemical Property of methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

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Technology Process of methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

There total 7 articles about methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 245057-73-2
4-(3,4-dichloro-phenoxy)-piperidine

: 921204-71-9
methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 5 steps

1: triethylamine / dichloromethane / 2 h / 0 °C

2: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / acetone; water / 18 h / 20 °C

3: borane-THF / tetrahydrofuran / 2 h / Reflux

4: acetic acid; sodium periodate / water / 1 h / 20 °C

5: sodium triacetoxy borohydride; acetic acid / 18 h / 20 °C

With potassium osmate(VI) dihydrate; sodium periodate; borane-THF; sodium triacetoxy borohydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; In tetrahydrofuran; dichloromethane; water; acetone;
DOI:10.1016/j.bmcl.2012.08.103

Reference yield:

: 676517-52-5
1-(3-cyclopenten-1-ylcarbonyl)-4-(3,4-dichlorophenoxy)piperidine

: 921204-71-9
methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium osmate(VI) dihydrate; 4-methylmorpholine N-oxide / acetone; water / 18 h / 20 °C

2: borane-THF / tetrahydrofuran / 2 h / Reflux

3: acetic acid; sodium periodate / water / 1 h / 20 °C

4: sodium triacetoxy borohydride; acetic acid / 18 h / 20 °C

With potassium osmate(VI) dihydrate; sodium periodate; borane-THF; sodium triacetoxy borohydride; acetic acid; 4-methylmorpholine N-oxide; In tetrahydrofuran; water; acetone;
DOI:10.1016/j.bmcl.2012.08.103

Reference yield:

: 676517-53-6
4-(3,4-dichlorophenoxy)-1-[(3,4-dihydroxycyclopentyl)carbonyl]piperidine

: 921204-71-9
methyl (2S)-2-(4-{[4-(3,4-dichlorophenoxy)piperidin-1-yl]methyl}piperidin-1-yl)-3-(4-fluorophenyl)-2-methylpropanoate

Guidance literature:: Multi-step reaction with 3 steps

1: borane-THF / tetrahydrofuran / 2 h / Reflux

2: acetic acid; sodium periodate / water / 1 h / 20 °C

3: sodium triacetoxy borohydride; acetic acid / 18 h / 20 °C

With sodium periodate; borane-THF; sodium triacetoxy borohydride; acetic acid; In tetrahydrofuran; water;
DOI:10.1016/j.bmcl.2012.08.103