Rivastigmine EP Impurity E

Base Information

Chemical Name:Rivastigmine EP Impurity E
CAS No.:923035-05-6
Molecular Formula:C₁₃H₂₀N₂O₂
Molecular Weight:236.314
Hs Code.:
Mol file:923035-05-6.mol

Synonyms:(S)-3-[1-(methylamino)ethyl]-phenyl N-ethyl-N-methyl-carbamate

Suppliers and Price of Rivastigmine EP Impurity E

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Namino-DesmethylRivastigmine
25mg
$ 725.00

Total 5 raw suppliers

Chemical Property of Rivastigmine EP Impurity E

Chemical Property:

Boiling Point:321.3±34.0 °C(Predicted)
PKA:9.28±0.10(Predicted)
Density:1.044±0.06 g/cm3(Predicted)

Purity/Quality:

98% HPLC ^*data from raw suppliers

Namino-DesmethylRivastigmine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Uses Namino-Desmethyl Rivastigmine (Rivastigmine EP Impurity E) is an impurity of Rivastigmine (R541000) which is a brain selective acetylcholinesterase inhibitor used in treatment of mild to moderate dementia.

Technology Process of Rivastigmine EP Impurity E

There total 2 articles about Rivastigmine EP Impurity E which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1017234-25-1
3-[(1S)-1-{methyl[(1S)-1-phenylethyl]amino}ethyl]phenyl N-ethyl-N-methylcarbamate

: 923035-05-6
(S)-3-[1-(methylamino)ethyl]-phenyl N-ethyl-N-methyl-carbamate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 60 ℃; for 12h; under 7600.51 Torr; regioselective reaction;
DOI:10.1080/00397910802531948

Reference yield:

: 894079-42-6
3-[(S)-1-(methylamino)ethyl]phenol

: 42252-34-6
N-ethyl-N-methylcarbamoyl chloride

: 923035-05-6
(S)-3-[1-(methylamino)ethyl]-phenyl N-ethyl-N-methyl-carbamate

Guidance literature:: 3-[(S)-1-(methylamino)ethyl]phenol; With sodium hydride; In tetrahydrofuran; at -5 - 0 ℃; for 0.75h;

N-ethyl-N-methylcarbamoyl chloride; In tetrahydrofuran; toluene; at 20 - 25 ℃; Product distribution / selectivity;

Reference yield: 79.3%

: 50-00-0,30525-89-4,61233-19-0
formaldehyd

: 923035-05-6
(S)-3-[1-(methylamino)ethyl]-phenyl N-ethyl-N-methyl-carbamate

: 123441-03-2,415973-05-6
rivastigmin

Guidance literature:: formaldehyd; (S)-3-[1-(methylamino)ethyl]-phenyl N-ethyl-N-methyl-carbamate; With formic acid; In water; at 20 ℃; Reflux;

With sodium carbonate; In water; at 20 ℃; pH=8;