P-AMINOCLONIDINE

Base Information

Chemical Name:P-AMINOCLONIDINE
CAS No.:73217-88-6
Molecular Formula:C₉H₁₀Cl₂N₄*ClH
Molecular Weight:281.572
Hs Code.:
Mol file:73217-88-6.mol

Synonyms:1,4-Benzenediamine,2,6-dichloro-N1-(4,5-dihydro-1H-imidazol-2-yl)-, dihydrochloride (9CI);Apraclonidine dihydrochloride; p-Aminoclonidine dihydrochloride

Suppliers and Price of P-AMINOCLONIDINE

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
p-AminoclonidineDihydrochloride
2.5mg
$ 240.00

TRC
p-AminoclonidineDihydrochloride
1mg
$ 120.00

American Custom Chemicals Corporation
APRACLONIDINE DIHYDROCHLORIDE 95.00%
5MG
$ 501.36

Total 4 raw suppliers

Chemical Property of P-AMINOCLONIDINE

Chemical Property:

PSA：62.44000
LogP:3.96930

Purity/Quality:

99% ^*data from raw suppliers

p-AminoclonidineDihydrochloride ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses a2-adrenoceptor agonist, antiglaucoma agent

Technology Process of P-AMINOCLONIDINE

There total 4 articles about P-AMINOCLONIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 66711-21-5
para-aminoclonidine

: 73217-88-6,87913-86-8
p-aminoclonidine hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; water; for 0.5h; Reflux;
DOI:10.1080/00304948.2016.1206429

Reference yield:

: 70106-94-4
N-(2,6-dichloro-4-nitrophenyl)formamide

: 73217-88-6,87913-86-8
p-aminoclonidine hydrochloride

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuryl dichloride; thionyl chloride / 60 °C

2.1: triethylamine / tetrahydrofuran / 0.25 h / Cooling with ice

2.2: 6.5 h / 5 - 20 °C

3.1: 5%-palladium/activated carbon; hydrazine hydrate / ethanol / 8 h / Reflux

4.1: hydrogenchloride / ethanol; water / 0.5 h / Reflux

With hydrogenchloride; thionyl chloride; sulfuryl dichloride; hydrazine hydrate; 5%-palladium/activated carbon; triethylamine; In tetrahydrofuran; ethanol; water;
DOI:10.1080/00304948.2016.1206429

Reference yield:

: 73218-65-2
(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

: 73217-88-6,87913-86-8
p-aminoclonidine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / Cooling with ice

1.2: 6.5 h / 5 - 20 °C

2.1: 5%-palladium/activated carbon; hydrazine hydrate / ethanol / 8 h / Reflux

3.1: hydrogenchloride / ethanol; water / 0.5 h / Reflux

With hydrogenchloride; hydrazine hydrate; 5%-palladium/activated carbon; triethylamine; In tetrahydrofuran; ethanol; water;
DOI:10.1080/00304948.2016.1206429