(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

Base Information

• Chemical Name: (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride
• CAS No.: 73218-65-2
• Molecular Formula: C₇H₂Cl₄N₂O₂
• Molecular Weight: 287.917
• Mol file: 73218-65-2.mol

Synonyms:(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

Chemical Property of (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

There total 2 articles about (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(2,6-dichloro-4-nitrophenyl)formamide (70106-94-4) → (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride (73218-65-2)

Guidance literature:

With thionyl chloride; sulfuryl dichloride; at 60 ℃; for 16h;

DOI:10.1021/jm00390a021

Reference yield:

4-nitro-2,6-dichloroaniline (99-30-9) → (2,6-dichloro-4-nitrophenyl)carbonimidic dichloride (73218-65-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride / 0.33 h / 55 - 60 °C

1.2: 6.33 h / 55 °C

2.1: sulfuryl dichloride; thionyl chloride / 60 °C

With thionyl chloride; sulfuryl dichloride; acetic anhydride;

DOI:10.1080/00304948.2016.1206429

Reference yield: 62.4%

(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride (73218-65-2) + ethylenediamine (107-15-3,85404-18-8) → 2-(2',6'-dichloro-4'-nitroanilino)-2-imidazoline (65936-26-7)

Guidance literature:

With triethylamine; In ethyl acetate; at 5 ℃; for 6h;

upstream raw materials:

N-(2,6-dichloro-4-nitrophenyl)formamide

4-nitro-2,6-dichloroaniline

Downstream raw materials:

2-(2',6'-dichloro-4'-nitroanilino)-2-imidazoline

2-({2,6-dichloro-4-[3,3-(1,4-butanediyl)triazeno]phenyl}imino)imidazolidine

p-Nitroclonidine

para-aminoclonidine

Refernces

• 1、 Zhang, He-Hui,An, Yu-Long,Xin, Wei-Xiang,Zhao, Sheng-Yin. "An Improved Procedure for the Preparation of Apraclonidine Hydrochloride". . p. 401 - 404. Retrieved 2016/09/14.