Apraclonidine

Base Information

Chemical Name:Apraclonidine
CAS No.:66711-21-5
Molecular Formula:C9H10Cl2N4
Molecular Weight:245.111
Hs Code.:2933290090
European Community (EC) Number:636-293-2
UNII:843CEN85DI
DSSTox Substance ID:DTXSID1048415
Nikkaji Number:J247.956G
Wikipedia:Apraclonidine
Wikidata:Q4781812
NCI Thesaurus Code:C61640
RXCUI:14845
Pharos Ligand ID:1NQSHR3BBNW5
Metabolomics Workbench ID:43220
ChEMBL ID:CHEMBL647

Synonyms:2-(4-amino-2,6-dichloro)phenyliminoimidazolidine;4-aminoclonidine;ALO 2145;ALO-2145;apraclonidine;apraclonidine hydrochloride;Iopidine;Iopimax;p-aminoclonidine;para-aminoclonidine

Suppliers and Price of Apraclonidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Apraclonidine 95+%
1g
$ 274.00

AvaChem
Apraclonidine
100mg
$ 209.00

AvaChem
Apraclonidine
25mg
$ 89.00

AvaChem
Apraclonidine
10mg
$ 59.00

AvaChem
Apraclonidine
5mg
$ 39.00

American Custom Chemicals Corporation
APRACLONIDINE 95.00%
10MG
$ 813.76

American Custom Chemicals Corporation
APRACLONIDINE 95.00%
1MG
$ 600.32

AHH
Apraclonidine 98%
1g
$ 360.00

Total 44 raw suppliers

Chemical Property of Apraclonidine

Chemical Property:

Vapor Pressure:1.83E-06mmHg at 25°C
Melting Point:>230°
Boiling Point:395.5 °C at 760 mmHg
Flash Point:193 °C
PSA：62.44000
Density:1.63 g/cm³
LogP:3.16730
Storage Temp.:2-8°C
Solubility.:45% (w/v) aq 2-hydroxypropyl-β-cyclodextrin: 1.4 mg/mL
XLogP3:1.3
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:2
Exact Mass:244.0282517
Heavy Atom Count:15
Complexity:247

Purity/Quality:

97% ^*data from raw suppliers

Apraclonidine 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s): T
Hazard Codes:T
Statements: 23/24/25
Safety Statements: 22-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Canonical SMILES:C1CN=C(N1)NC2=C(C=C(C=C2Cl)N)Cl
Recent ClinicalTrials:Efficacy of Topical Apraclonidine for the Treatment of Ocular Synkinesis

Technology Process of Apraclonidine

There total 9 articles about Apraclonidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 65936-26-7,741202-17-5
p-Nitroclonidine

: 66711-21-5
para-aminoclonidine

Guidance literature:: With hydrazine hydrate; 5%-palladium/activated carbon; In ethanol; for 8h; Reflux;
DOI:10.1080/00304948.2016.1206429

Reference yield: 77.0%

: 65936-26-7
2-(2',6'-dichloro-4'-nitroanilino)-2-imidazoline

: 66711-21-5
p-aminoclonidine

Guidance literature:: With hydrogenchloride; iron; In ethanol; for 3h; Heating;
DOI:10.1021/jm00390a021

Reference yield:

: 73218-65-2
(2,6-dichloro-4-nitrophenyl)carbonimidic dichloride

: 66711-21-5
para-aminoclonidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / tetrahydrofuran / 0.25 h / Cooling with ice

1.2: 6.5 h / 5 - 20 °C

2.1: 5%-palladium/activated carbon; hydrazine hydrate / ethanol / 8 h / Reflux

With hydrazine hydrate; 5%-palladium/activated carbon; triethylamine; In tetrahydrofuran; ethanol;
DOI:10.1080/00304948.2016.1206429