2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde

Base Information

Chemical Name:2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde
CAS No.:628332-42-3
Molecular Formula:C₂₃H₂₄F₃N₃O₃
Molecular Weight:447.457
Hs Code.:

Synonyms:2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde

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Chemical Property of 2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde

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Technology Process of 2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde

There total 12 articles about 2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 628329-76-0
3-{3-isopropyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}-1-propanol

: 148-53-8
3-methoxy-2-hydroxybenzaldehyde

: 124-63-0
methanesulfonyl chloride

: 628332-42-3
2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde

Guidance literature:: 3-{3-isopropyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}-1-propanol; methanesulfonyl chloride; With triethylamine; In tetrahydrofuran; at 0 ℃; for 1.5h;

3-methoxy-2-hydroxybenzaldehyde; With potassium carbonate; In acetonitrile; for 2.5h; Heating / reflux;

Reference yield:

: 563-80-4
3-methyl-butan-2-one

: 628332-42-3
2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 6 steps

1.1: 8 h / Heating / reflux

1.2: 6 h / Heating / reflux

2.1: sodium hydroxide / 1-methyl-pyrrolidin-2-one / 9 h / 20 °C

3.1: ammonium cerium(IV) nitrate; iodine / acetonitrile / 5 h / 20 °C

4.1: sodium hydrogencarbonate; triphenylphosphine / palladium diacetate; N-benzyl-N,N,N-triethylammonium chloride / 1-methyl-pyrrolidin-2-one; water / 7 h / 20 - 60 °C

5.1: sodium tetrahydroborate / methanol / 1 h / 0 °C

6.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

6.2: 2.5 h / Heating / reflux

With sodium hydroxide; sodium tetrahydroborate; ammonium cerium(IV) nitrate; iodine; sodium hydrogencarbonate; triethylamine; triphenylphosphine; palladium diacetate; N-benzyl-N,N,N-triethylammonium chloride; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; acetonitrile;

Reference yield:

: ethyl (E)-3-{3-isopropyl-1-[5-(trifluoromethyl)-2-pyridyl]-1H-pyrazol-4-yl}propenoate

: 628332-42-3
2-(3-{3-isopropyl-1-[5-(trifluoromethyl)pyridin-2-yl]-1H-pyrazol-4-yl}propoxy)-3-methoxybenzaldehyde

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / 5%-palladium/activated carbon / tetrahydrofuran / 1 h / 20 °C

2.1: diisobutylaluminium hydride / tetrahydrofuran; hexane / 1 h / 0 - 20 °C

3.1: triethylamine / tetrahydrofuran / 1.5 h / 0 °C

3.2: 2.5 h / Heating / reflux

With hydrogen; diisobutylaluminium hydride; triethylamine; 5%-palladium/activated carbon; In tetrahydrofuran; hexane;