(3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

Base Information

Chemical Name:(3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate
CAS No.:1025068-99-8
Molecular Formula:C₅₁H₈₀FNO₅Si
Molecular Weight:834.284
Hs Code.:

Synonyms:(3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

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Chemical Property of (3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

Chemical Property:

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Technology Process of (3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

There total 11 articles about (3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025068-98-7
4-fluoro-N-[[(3β)-3-hydroxylup-20(29)-en-28-yl]methyl]phenylacetamide

: 141850-59-1
3,3-dimethylglutaric acid mono<2-(trimethylsilyl)ethanyl> ester

: 1025068-99-8
(3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

Guidance literature:: With dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride; In dichloromethane; at 20 ℃; for 16h;

Reference yield:

: 10376-50-8,38736-81-1
3-O-acetylbetulinic acid

: 1025068-99-8
(3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

Guidance literature:: Multi-step reaction with 7 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2.2: 72 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / -10 - 20 °C

3.2: 0 °C

4.1: ammonium acetate / 3 h / 120 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 5 - 20 °C

6.1: triethylamine / dichloromethane / 16 h / 20 °C

7.1: dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride / dichloromethane / 16 h / 20 °C

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

Betulinic acid: 472-15-1
Betulinic acid

: 1025068-99-8
(3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

Guidance literature:: Multi-step reaction with 8 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 65 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3.2: 72 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / -10 - 20 °C

4.2: 0 °C

5.1: ammonium acetate / 3 h / 120 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 5 - 20 °C

7.1: triethylamine / dichloromethane / 16 h / 20 °C

8.1: dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride / dichloromethane / 16 h / 20 °C

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; ammonium acetate; triethylamine; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;