(3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate

Base Information

Chemical Name:(3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate
CAS No.:1025069-72-0
Molecular Formula:C₄₆H₆₈FNO₅
Molecular Weight:734.048
Hs Code.:

Synonyms:(3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate

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Chemical Property of (3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate

Chemical Property:

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Technology Process of (3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate

There total 11 articles about (3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1025068-99-8
(3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate

: 1025069-72-0
(3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate

Guidance literature:: (3β)-28-[[[[2-(4-fluorophenyl)-1-oxo]ethyl]amino]methyl]lup-20(29)-en-3-ol; 2-trimethylsilylethyl 3,3-dimethylpentanedioate; With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 24h;

With silica gel; In methanol; dichloromethane;

Reference yield:

: 10376-50-8,38736-81-1
3-O-acetylbetulinic acid

: 1025069-72-0
(3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate

Guidance literature:: Multi-step reaction with 8 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

2.2: 72 h / 20 °C

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / -10 - 20 °C

3.2: 0 °C

4.1: ammonium acetate / 3 h / 120 °C

5.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 5 - 20 °C

6.1: triethylamine / dichloromethane / 16 h / 20 °C

7.1: dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride / dichloromethane / 16 h / 20 °C

8.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; ammonium acetate; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

Betulinic acid: 472-15-1
Betulinic acid

: 1025069-72-0
(3β)-28-[[[(2-(4-fluorophenyl)-1-oxo)ethyl]amino]methyl]lup-20(29)-en-3-ol; hydrogen 3,3-dimethylpentanedioate

Guidance literature:: Multi-step reaction with 9 steps

1.1: dmap; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 65 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 6 h / 0 - 20 °C

3.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 °C

3.2: 72 h / 20 °C

4.1: lithium aluminium tetrahydride / tetrahydrofuran / 72 h / -10 - 20 °C

4.2: 0 °C

5.1: ammonium acetate / 3 h / 120 °C

6.1: lithium aluminium tetrahydride / tetrahydrofuran / 16 h / 5 - 20 °C

7.1: triethylamine / dichloromethane / 16 h / 20 °C

8.1: dmap; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride / dichloromethane / 16 h / 20 °C

9.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 24 h

With dmap; lithium aluminium tetrahydride; oxalyl dichloride; ammonium acetate; tetrabutyl ammonium fluoride; triethylamine; N-ethyl-N,N-diisopropylamine; 2,6-Dichlorobenzoyl chloride; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;