Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate

Base Information

Chemical Name:Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate
CAS No.:161111-15-5
Molecular Formula:C₁₅H₁₉NO₅
Molecular Weight:293.32
Hs Code.:

Methyl (1S,2R)-1-<N-((Benzyloxy)carbonyl)amino>-2-(2-hydroxyethyl)cyclopropanecarboxylate

Synonyms:Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate

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Chemical Property of Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate

Chemical Property:

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Technology Process of Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate

There total 9 articles about Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 161111-11-1
Di-tert-butyl (R)-2-(2-(benzyloxy)ethyl)cyclopropane-1,1-dicarboxylate

: 161111-15-5
Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / H₂ / 10percent Pd/C / methanol

2: CF₃COOH / CH₂Cl₂ / Heating

3: TEA / acetone / 0.5 h

4: NaN₃ / acetone; H₂O / 0.5 h

5: Heating

6: aq. LiOH / tetrahydrofuran / Ambient temperature

7: K₂CO₃ / acetonitrile; dimethylformamide

With lithium hydroxide; sodium azide; TEA; hydrogen; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo00097a040

Reference yield:

: 161111-10-0
Di-tert-butyl (4-(benzyloxy)-(S)-2-(tosyloxy)butyl)malonate

: 161111-15-5
Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 8 steps

1: 93 percent / KHMDS / tetrahydrofuran / 1.) -78 to 0 deg C, 20 min, 2.) 0 deg C, 20 min

2: 99 percent / H₂ / 10percent Pd/C / methanol

3: CF₃COOH / CH₂Cl₂ / Heating

4: TEA / acetone / 0.5 h

5: NaN₃ / acetone; H₂O / 0.5 h

6: Heating

7: aq. LiOH / tetrahydrofuran / Ambient temperature

8: K₂CO₃ / acetonitrile; dimethylformamide

With lithium hydroxide; sodium azide; TEA; hydrogen; potassium hexamethylsilazane; potassium carbonate; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; acetonitrile;
DOI:10.1021/jo00097a040

Reference yield:

: 1026581-60-1
(1R,6R)-2-Oxo-3-oxa-bicyclo[4.1.0]heptane-1-carbonyl azide

: 161111-15-5
Methyl (1S,2R)-1--2-(2-hydroxyethyl)cyclopropanecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: Heating

2: aq. LiOH / tetrahydrofuran / Ambient temperature

3: K₂CO₃ / acetonitrile; dimethylformamide

With lithium hydroxide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jo00097a040