2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane

Base Information

• Chemical Name: 2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane
• CAS No.: 264881-24-5
• Molecular Formula: C₁₄H₂₀FN₂O₂P
• Molecular Weight: 298.297

Synonyms:2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane

Chemical Property of 2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane

Chemical Property:

Purity/Quality:

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Technology Process of 2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane

There total 2 articles about 2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

hexaethylphosphoric triamide (2283-11-6) + (+/-)-2-[N-(2-fluoroacetyl)]amino-1-phenylethanol (264881-21-2) → 2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane (264881-24-5)

Guidance literature:

at 120 ℃; for 3h;

DOI:10.1021/ja991773u

Reference yield:

2-Amino-1-phenylethanol (7568-93-6,1936-63-6) → 2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane (264881-24-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 72 percent / 2 h / 130 °C

2: 76 percent / 3 h / 120 °C

1: Condensation / 2: Cyclization;

DOI:10.1021/ja991773u

Reference yield:

4-N-Benzoyl-2'-deoxy-5'-O-(4,4'-dimethoxytrityl)cytidine (67219-55-0) + 2-(N,N-diethylamino)-3-(2-fluoroacetyl)-5-phenyl-1,3,2-oxazaphospholane (264881-24-5) → N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2R,5R)-3-(2-fluoro-acetyl)-5-phenyl-[1,3,2]oxazaphospholidin-2-yloxy]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide (264881-16-5) + N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2S,5S)-3-(2-fluoro-acetyl)-5-phenyl-[1,3,2]oxazaphospholidin-2-yloxy]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide (264881-45-0)

Guidance literature:

With 1H-tetrazole; In acetonitrile; at 20 ℃; for 0.25h;

DOI:10.1021/ja991773u

upstream raw materials:

hexaethylphosphoric triamide

(+/-)-2-[N-(2-fluoroacetyl)]amino-1-phenylethanol

2-Amino-1-phenylethanol

Downstream raw materials:

N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2R,5R)-3-(2-fluoro-acetyl)-5-phenyl-[1,3,2]oxazaphospholidin-2-yloxy]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

N-(1-{(2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-[(2S,5S)-3-(2-fluoro-acetyl)-5-phenyl-[1,3,2]oxazaphospholidin-2-yloxy]-tetrahydro-furan-2-yl}-2-oxo-1,2-dihydro-pyrimidin-4-yl)-benzamide

C₅₉H₆₀FN₆O₁₅P

C₆₃H₆₅FN₉O₁₅P

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