methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester

Base Information

• Chemical Name: methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester
• CAS No.: 149105-94-2
• Molecular Formula: C₁₉H₂₃NO₃S
• Molecular Weight: 345.463
• Mol file: 149105-94-2.mol

Synonyms:methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester

Chemical Property of methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester

There total 1 articles about methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

methanesulfonyl chloride (124-63-0) + 1-(diphenylmethyl)-3-ethyl-3-azetidinol (147293-65-0) → methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester (149105-94-2)

Guidance literature:

With triethylamine;

DOI:10.1016/j.bmcl.2007.01.090

Reference yield: 86.0%

methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester (149105-94-2) + sodium cyanide (143-33-9,25596-52-5) → 1-benzhydryl-3-ethyl-azetidine-3-carbonitrile (852655-70-0)

Guidance literature:

In water; N,N-dimethyl-formamide; at 60 ℃;

DOI:10.1016/j.bmcl.2007.01.090

Reference yield:

methanesulfonic acid 1-benzhydryl-3-ethyl-azetidin-3-yl ester (149105-94-2) + N-benzhydryl 3-azetidinone (40320-60-3) + ethylmagnesium bromide (925-90-6) + 1-(diphenylmethyl)-3-ethyl-3-azetidinol (147293-65-0) → 3-amino-1-benzhydryl-3-ethylazetidine (149105-93-1)

Guidance literature:

With ammonia; In ethanol;

upstream raw materials:

methanesulfonyl chloride

1-(diphenylmethyl)-3-ethyl-3-azetidinol

Downstream raw materials:

1-benzhydryl-3-ethyl-azetidine-3-carbonitrile

C-(1-benzhydryl-3-ethyl-azetidin-3-yl)-methylamine

N-(1-benzhydryl-3-ethyl-azetidin-3-ylmethyl)-2,2,2-trifluoro-acetamide

3-amino-1-benzhydryl-3-ethylazetidine