4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid

Base Information

• Chemical Name: 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid
• CAS No.: 77270-62-3
• Molecular Formula: C₂₀H₂₃NO₆
• Molecular Weight: 373.406
• Mol file: 77270-62-3.mol

Synonyms:4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid

Chemical Property of 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid

There total 4 articles about 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester (77270-61-2) → 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid (77270-62-3)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; ethanol; for 1h; Ambient temperature;

DOI:10.1021/jo00324a054

Reference yield:

3-(2-Methoxy-ethoxymethoxy)-2-nitro-phenol (77270-58-7) → 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid (77270-62-3)

Guidance literature:

Multi-step reaction with 4 steps

1: 100 percent / H₂, NaBH₄, 2 N NaOH / 10percent Pd/C / 0.5 h / Ambient temperature

2: 98 percent / K₂CO₃ / acetone / 12 h / Heating

3: 96 percent / NaI, K₂CO₃ / acetone / 15 h / 90 °C

4: 100 percent / 5percent KOH / ethanol; tetrahydrofuran / 1 h / Ambient temperature

With potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In tetrahydrofuran; ethanol; acetone;

DOI:10.1021/jo00324a054

Reference yield:

2-Amino-3-(2-methoxy-ethoxymethoxy)-phenol (77270-59-8) → 4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid (77270-62-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / K₂CO₃ / acetone / 12 h / Heating

2: 96 percent / NaI, K₂CO₃ / acetone / 15 h / 90 °C

3: 100 percent / 5percent KOH / ethanol; tetrahydrofuran / 1 h / Ambient temperature

With potassium hydroxide; potassium carbonate; sodium iodide; In tetrahydrofuran; ethanol; acetone;

DOI:10.1021/jo00324a054

upstream raw materials:

4-Benzyl-5-(2-methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

2-Amino-3-(2-methoxy-ethoxymethoxy)-phenol

3-(2-Methoxy-ethoxymethoxy)-2-nitro-phenol

5-(2-Methoxy-ethoxymethoxy)-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester

Downstream raw materials:

(5aR,9aS)-4-Acetyl-8-methoxy-2,7-dimethyl-5,10-dioxo-9-phenylsulfanyl-3,4,5,5a,6,9,9a,10-octahydro-2H-naphtho[2,3-b][1,4]oxazine-2-carboxylic acid methyl ester

4-Benzyl-5-(2-methoxy-ethoxymethoxy)-2-methyl-3,4-dihydro-2H-benzo[1,4]oxazine-2-carboxylic acid methyl ester