(7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

Base Information

Chemical Name:(7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid
CAS No.:1610458-13-3
Molecular Formula:C₂₃H₂₂F₃N₃O₄
Molecular Weight:461.441
Hs Code.:

Synonyms:(7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

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Chemical Property of (7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

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Technology Process of (7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

There total 10 articles about (7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1384175-82-9
(7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

: 1610458-13-3
(7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: With potassium carbonate; In methanol; at 20 ℃;

Reference yield:

: 1384175-49-8
8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carbonitrile

: 1610458-13-3
(7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2: hydrogenchloride / water / 24 h / 100 °C / pH 12

3: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

4: hydrogenchloride / water / 100 °C

5: potassium carbonate / methanol / 20 °C

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1384175-73-8
(7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxamide

: 1610458-13-3
(7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride / water / 100 °C

2: potassium carbonate / methanol / 20 °C

With hydrogenchloride; potassium carbonate; In methanol; water;