tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Base Information

Chemical Name:tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate
CAS No.:1610458-14-4
Molecular Formula:C₂₃H₂₄F₃N₅O₃
Molecular Weight:475.47
Hs Code.:

Synonyms:tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

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Chemical Property of tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

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Technology Process of tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

There total 11 articles about tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1610458-13-3
(7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid

: 1610458-14-4
tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: (7R,8S)-8-((tert-butoxycarbonyl)amino)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxylic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

With hydrazine hydrate; at 0 - 20 ℃; for 3h;

Reference yield:

: 1384175-49-8
8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carbonitrile

: 1610458-14-4
tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 6 steps

1.1: benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 20 °C

2.1: hydrogenchloride / water / 24 h / 100 °C / pH 12

3.1: potassium carbonate; dihydrogen peroxide / dimethyl sulfoxide / 2.33 h / 0 - 20 °C

4.1: hydrogenchloride / water / 100 °C

5.1: potassium carbonate / methanol / 20 °C

6.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

6.2: 3 h / 0 - 20 °C

With hydrogenchloride; dihydrogen peroxide; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In methanol; water; dimethyl sulfoxide; N,N-dimethyl-formamide;

Reference yield:

: 1384175-73-8
(7R,8S)-8-amino-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridine-3-carboxamide

: 1610458-14-4
tert-butyl ((7R,8S)-3-(hydrazinecarbonyl)-7-(2,4,5-trifluorophenyl)-6,7,8,9-tetrahydrobenzo[4,5]imidazo[1,2-a]pyridin-8-yl)carbamate

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogenchloride / water / 100 °C

2.1: potassium carbonate / methanol / 20 °C

3.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 3 h / 0 - 20 °C

With hydrogenchloride; potassium carbonate; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; water; N,N-dimethyl-formamide;