1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

Base Information

Chemical Name:1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone
CAS No.:1225436-56-5
Molecular Formula:C₃₆H₄₉F₂N₃O₅S
Molecular Weight:673.865
Hs Code.:

1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

Synonyms:1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

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Chemical Property of 1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

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Technology Process of 1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

There total 19 articles about 1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1072354-77-8
({(2S)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methoxy)acetic acid

: 1225437-12-6
9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane

: 1225436-56-5
1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

Guidance literature:: ({(2S)-1-[(4-methoxy-2,6-dimethylphenyl)sulfonyl]piperidin-2-yl}methoxy)acetic acid; With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 0 - 20 ℃;

9-(3,3-Difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecane; In tetrahydrofuran; at 0 - 20 ℃;

Reference yield:

: 2971-79-1
isonipecotic acid methyl ester

: 1225436-56-5
1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

Guidance literature:: Multi-step reaction with 9 steps

1.1: triethylamine / dichloromethane / 12 h / 25 °C

2.1: lithium borohydride / tetrahydrofuran / 0 °C / Reflux

3.1: pyridinium chlorochromate / dichloromethane / 0 - 25 °C

4.1: potassium hydroxide / tetrahydrofuran; ethanol / 0 - 25 °C

5.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 25 °C

6.1: acetic acid / methanol; water / 0 - 20 °C

6.2: Cooling with ice

7.1: tetrahydrofuran / 0 - 20 °C

8.1: trifluoroacetic acid / dichloromethane / 3 h

9.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0 - 20 °C

9.2: 0 - 20 °C

With lithium borohydride; hydrogen; acetic acid; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; pyridinium chlorochromate; trifluoroacetic acid; potassium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water; 3.1: Swern Oxidation;

Reference yield:

: 873924-07-3
9-oxo-3-azaspiro[5.5]undec-7-ene-3-carboxylic acid tert-butyl ester

: 1225436-56-5
1-(9-(3,3-difluoroazetidin-1-yl)-9-phenyl-3-azaspiro[5.5]undecan-3-yl)-2-(((S)-1-(4-methoxy-2,6-dimethylphenylsulfonyl)piperidin-2-yl)methoxy)ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogen / palladium 10% on activated carbon / ethanol / 16 h / 25 °C

2.1: acetic acid / methanol; water / 0 - 20 °C

2.2: Cooling with ice

3.1: tetrahydrofuran / 0 - 20 °C

4.1: trifluoroacetic acid / dichloromethane / 3 h

5.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 0 - 20 °C

5.2: 0 - 20 °C

With hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; palladium 10% on activated carbon; In tetrahydrofuran; methanol; ethanol; dichloromethane; water;